Peptide Information

General Information of This Peptide
Peptide ID
BTDP005370
Peptide Name
Delta-buthitoxin-Hj1a
Symonym
Delta-BUTX-Hj1a
Species
Hottentotta judaicus (Black scorpion) (Buthotus judaicus)
Uniprot Name
DEL1A_HOTJU
Alphafold ID
P0DQN8
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6OHX
Sequence
EEVRDAYIAQPHNCVYHCFRDSYCNDLCIKHGAESGECKWFTSSGNACWCVKLPKSEPIK
VPGKCH
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Sequence Length
66
Mass (Da)
7491
Sequence Removed Signal Peptide
EEVRDAYIAQPHNCVYHCFRDSYCNDLCIKHGAESGECKWFTSSGNACWCVKLPKSEPIK
VPGKCH
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Disulfide Bond
14-65;18-38;24-48;28-50
PDB ID
6OHX
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Hottentotta
Species: Hottentotta judaicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Effective concentration 50
7.5 nM
 . . [1]
 Target Info    Nav1.5 Effective concentration 50
9.2 nM
 . . [1]
 Target Info    Nav1.1 Effective concentration 50
17 nM
 . . [1]
 Target Info    Nav1.6 Effective concentration 50
37.3 nM
 . . [1]
References
Ref 1 Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel Na(V)1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci. 2019 Nov 25;3(1):119-134. doi: 10.1021/acsptsci.9b00079. eCollection 2020 Feb 14.
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