Peptide Information

General Information of This Peptide
Peptide ID
BTDP006178
Peptide Name
Beta-mammal/insect toxin To1
Symonym
NaTx12.1; Toxin Tc49b
Species
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Uniprot Name
SCX1_TITOB
Alphafold ID
P60214
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P60214
Sequence
MTRFVLFISCFFLIDMIVECKKEGYLVGNDGCKYGCITRPHQYCVHECELKKGTDGYCAY
WLACYCYNMPDWVKTWSSATNKCKGK
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Sequence Length
86
Mass (Da)
10008
Signal Sequence
MTRFVLFISCFFVIGMVVEC
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Sequence Removed Signal Peptide
KKEGYLVGNDGCKYGCITRPHQYCVHECELKKGTDGYCAYWLACYCYNMPDWVKTWSSAT
NKCKGK
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Disulfide Bond
32-83;36-58;44-64;48-66
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Inhibition rate
20 %
70 nM
Reduce peak current
 [1- 5]
 Target Info    Nav1.2 Inhibition rate
42.7 %
70 nM
Reduce peak current
 [1- 5]
 Target Info    Nav1.5 Inhibition rate
46.7 %
70 nM
Reduce peak current
 [1- 5]
 Target Info    Nav1.1 Inhibition rate
53.3 %
70 nM
Reduce peak current
 [1- 5]
 Target Info    Nav1.6 Inhibition rate
55.3 %
70 nM
Reduce peak current
 [1- 5]
 Target Info    Nav1.3 Inhibition rate
80 %
70 nM
Reduce peak current
 [1- 5]
References
Ref 1 Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins. PLoS One. 2012;7(2):e30478. doi: 10.1371/journal.pone.0030478. Epub 2012 Feb 15.
Ref 2 Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One. 2018 Mar 21;13(3):e0193739. doi: 10.1371/journal.pone.0193739. eCollection 2018.
Ref 3 Scorpion toxins from Tityus cambridgei that affect Na(+)-channels. Toxicon. 2002 May;40(5):557-62. doi: 10.1016/s0041-0101(01)00252-5.
Ref 4 Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):55-66. doi: 10.1016/j.jchromb.2003.09.002.
Ref 5 Electrophysiological characterization of Tityus obscurus toxin 1 (To1) on Na(+)-channel isoforms. Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):142-150. doi: 10.1016/j.bbamem.2018.08.005. Epub 2018 Aug 14.
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