Peptide Information

General Information of This Peptide
Peptide ID
BTDP002081
Peptide Name
Kappa-theraphotoxin-Cg1a 4
Symonym
Jingzhaotoxin-11.4; Jingzhaotoxin-XI.4; Peptide F4-13.64
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZ11D_CHIGU
Alphafold ID
B1P1E2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: B1P1E2
Sequence
MKASVLITLAVLGVMFVWASAAELEERGSDQRDSPAWLKSMERIFQSEERECRKMFGGCS
VDSDCCAHLGCKPTLKYCAWDGTFGK
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Sequence Length
86
Mass (Da)
9571
Signal Sequence
MKASVLITLAVLGVMFVWASA
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Sequence Removed Signal Peptide
AELEERGSDQRDSPAWLKSMERIFQSEERECRKMFGGCSVDSDCCAHLGCKPTLKYCAWD
GTFGK
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Disulfide Bond
52-66;59-71;65-78
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Inhibition rate
100 %
5 μM
Complete inhibition
 [1], [2], [3], [4]
 Target Info    Kv4.1 Inhibition rate
Moderate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Kv4.2 Inhibition rate
Moderate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.5 Effective concentration 50
1.18 μM
 .
Fast inactivation
 [1], [2], [3], [4]
 Target Info    Nav1.5 IC50
124 nM
 .
Inhibit sodium conductance
 [1], [2], [3], [4]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels. Biochemistry. 2006 Dec 26;45(51):15591-600. doi: 10.1021/bi061457+.
Ref 4 The tarantula toxin jingzhaotoxin-XI (-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5. Toxicon. 2014 Dec 15;92:6-13. doi: 10.1016/j.toxicon.2014.09.002. Epub 2014 Sep 18.
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