Peptide Information

General Information of This Peptide
Peptide ID
BTDP002909
Peptide Name
Mu-conotoxin BuIIIC
Species
Conus bullatus (Bubble cone)
Uniprot Name
CM3C_CONBU
Alphafold ID
C1J5M7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2LU6
Sequence
MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDLSSEQHPLFEKRIVDRCCNKG
NGKRGCSRWCRDHSRCCGRR
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Sequence Length
80
Mass (Da)
9178
Signal Sequence
MMSKLGVLLTICLLLFPLFALP
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Sequence Removed Signal Peptide
QDGDQPADRPAERMQDDLSSEQHPLFEKRIVDRCCNKGNGKRGCSRWCRDHSRCCGRR
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Disulfide Bond
56-70;57-76;66-77
PDB ID
2LU6
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus bullatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Inhibition rate .
75 nM
 . [1], [2]
 Target Info    Nav1.5 Inhibition rate .
75 nM
 . [1], [2]
 Target Info    Nav1.3 Inhibition rate
10 %
75 nM
 . [1], [2]
 Target Info    Nav1.4 Inhibition rate
45 %
75 nM
 . [1], [2]
 Target Info    Nav1.6 Inhibition rate
45 %
75 nM
 . [1], [2]
 Target Info    Nav1.4 Inhibition rate
96 %
1 μM
 . [1], [2]
 Target Info    Nav1.2 IC50
34.1 nM
 . . [1], [2]
References
Ref 1 Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan;53(1):90-8. doi: 10.1016/j.toxicon.2008.10.017. Epub 2008 Nov 20.
Ref 2 Design of bioactive peptides from naturally occurring -conotoxin structures. J Biol Chem. 2012 Sep 7;287(37):31382-92. doi: 10.1074/jbc.M112.375733. Epub 2012 Jul 6.
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