Peptide Information

General Information of This Peptide
Peptide ID
BTDP008617
Peptide Name
Kappa-theraphotoxin-Cg1a 1
Symonym
Jingzhaotoxin-11; Jingzhaotoxin-XI; Peptide F4-13.64
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZ11A_CHIGU
Alphafold ID
P0C247
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2A2V
Sequence
MKVSVLITLAVLGVMFVWASAAELEERGSDQRDSPAWLKSMERIFQSGERECRKMFGGCS
VDSDCCAHLGCKPTLKYCAWDGTFGK
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Sequence Length
86
Mass (Da)
9527
Sequence Removed Signal Peptide
ECRKMFGGCSVDSDCCAHLGCKPTLKYCAWDGTF
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Disulfide Bond
52-66;59-71;65-78
PDB ID
2A2V , 3J5Q
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
760 nM
 .
Modifier
 [1], [2], [3]
 Target Info    Kv1.1 Inhibition rate .
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate .
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate .
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv3.1 Inhibition rate .
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv4.1 Inhibition rate
35 %
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv4.2 Inhibition rate
42 %
5 μM
Modifier
 [1], [2], [3]
 Target Info    Kv2.1 Inhibition rate
100 %
5 μM
Complete inhibition
 [1], [2], [3]
 Target Info    Kv4.1 Inhibition rate
Moderate .
5 μM
 . [1], [2], [3]
 Target Info    Kv4.2 Inhibition rate
Moderate .
5 μM
 . [1], [2], [3]
 Target Info    Nav1.5 Effective concentration 50
1.18 μM
 .
Slow the fast inactivation
[1], [2], [3]
 Target Info    Nav1.5 IC50
124 nM
 . . [1], [2], [3]
References
Ref 1 Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels. Biochemistry. 2006 Dec 26;45(51):15591-600. doi: 10.1021/bi061457+.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 The tarantula toxin jingzhaotoxin-XI (-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5. Toxicon. 2014 Dec 15;92:6-13. doi: 10.1016/j.toxicon.2014.09.002. Epub 2014 Sep 18.
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