Peptide Information

General Information of This Peptide
Peptide ID
BTDP008631
Peptide Name
Potassium channel toxin alpha-KTx 23.1
Symonym
Toxin Vm24; Toxin alpha-KTx 21.1
Species
Vaejovis mexicanus smithi (Mexican scorpion) (Vaejovis smithi)
Uniprot Name
KA231_VAEMS
Alphafold ID
P0DJ31
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2K9O
Sequence
AAAISCVGSPECPPKCRAQGCKNGKCMNRKCECYYC
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Sequence Length
36
Mass (Da)
3874
Sequence Removed Signal Peptide
AAAISCVGSPECPPKCRAQGCKNGKCMNRKCKCYYC
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Disulfide Bond
6-26;12-31;16-33;21-36
PDB ID
2K9O
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Vaejovidae
Genus: Vaejovis
Species: Vaejovis smithi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
2.9 pM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 Dissociation constant
3 pM
 .
Blocker
 [2]
 Target Info    Kv1.2 Dissociation constant
0.54 nM
 .
Blocker
 [2]
 Target Info    KCa3.1 Dissociation constant
0.59 nM
 .
Blocker
 [2]
 Target Info    Kv1.1 Dissociation constant
0.8 nM
 .
Blocker
 [2]
 Target Info    ERG Inhibition rate .
10 nM
Blocker
 [1], [2]
 Target Info    Kv2.1 Inhibition rate .
10 nM
Blocker
 [2]
 Target Info    Nav1.5 Inhibition rate .
10 nM
Blocker
 [1], [2]
 Target Info    Kv2.1 Inhibition rate .
10 nM
Blocker
 [1], [2]
 Target Info    Kv1.4 Inhibition rate .
10 nM
Blocker
 [2]
 Target Info    Kv1.4 Inhibition rate .
10 nM
Blocker
 [1], [2]
 Target Info    Kv1.5 Inhibition rate .
10 nM
Blocker
 [1], [2]
 Target Info    KCa2.3 Inhibition rate .
10 nM
Blocker
 [2]
 Target Info    Kv11 Inhibition rate .
10 nM
Blocker
 [2]
 Target Info    KCa1.1 Inhibition rate .
10 nM
Blocker
 [1], [2]
 Target Info    KCa1.1 Inhibition rate .
10 nM
Blocker
 [2]
References
Ref 1 Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry. 2012 May 15;51(19):4049-61. doi: 10.1021/bi300060n. Epub 2012 May 7.
Ref 2 Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. Mol Pharmacol. 2012 Sep;82(3):372-82. doi: 10.1124/mol.112.078006. Epub 2012 May 23.
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