General Information of This Target
Target ID
BTDT10260
Target Name
Sodium channel protein type 2 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu-conotoxin GVIIJ Dissociation constant
11 nM
[1- 5]
 Toxin Info    Mu-conotoxin KIIIB Dissociation constant
230 nM
[6- 18]
 Toxin Info    Mu-conotoxin KIIIB Dissociation constant
470 nM
[6- 18]
 Toxin Info    Venom peptide Sh41 Effect . [19]
 Toxin Info    Venom peptide Sh42 Effect . [19]
 Toxin Info    Toxin Acra3 Inhibition rate . [20], [21]
 Toxin Info    Beta-mammal toxin Css2 Inhibition rate . [22- 31]
 Toxin Info    Beta-toxin Cll2 Inhibition rate . [32], [29], [30]
 Toxin Info    Toxin Aah4 Inhibition rate . [33], [34], [35], [36]
 Toxin Info    Neurotoxic enhancer CSTX-13 Inhibition rate . [37], [38], [39], [40]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [41], [42]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [41], [42]
 Toxin Info    Delta-theraphotoxin-Hm1a Inhibition rate . [43], [44], [45], [46]
 Toxin Info    Beta-toxin Tf1a Inhibition rate
17 - 30 %
[47]
 Toxin Info    Beta-toxin To4 Inhibition rate
20-30 %
[48- 52]
 Toxin Info    Beta-toxin To4 Inhibition rate
40 - 50 %
[48- 52]
 Toxin Info    Beta-mammal/insect toxin To1 Inhibition rate
42.7 %
[48- 53]
 Toxin Info    Mu-theraphotoxin-Hd1a Inhibition rate
55 %
[54]
 Toxin Info    Alpha-like toxin BmK M1 Effective concentration 50
139 - 252 nM
[55- 68]
 Toxin Info    Delta-theraphotoxin-Hm1a Effective concentration 50
236 nM
[43], [44], [45], [46]
 Toxin Info    Alpha-toxin CvIV4 Effective concentration 50
580 nM
[69]
 Toxin Info    Delta-actitoxin-Bcs1a Effective concentration 50
1.44917 μM
[70], [71], [72]
 Toxin Info    Delta-conotoxin-like CnVID Effective concentration 50
1.7 μM
[73], [74]
 Toxin Info    Delta-actitoxin-Afv1b Effective concentration 50
1.998 μM
[71- 75]
 Toxin Info    Beta-theraphotoxin-Ps1a IC50
0.6 - 0.7 nM
[76], [77], [78]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
3 - 70 nM
[76- 80]
 Toxin Info    Beta-theraphotoxin-Cm1b IC50
3.7 - 80 nM
[76- 80]
 Toxin Info    Mu-conotoxin KIIIB IC50
5 - 124 nM
[6- 18]
 Toxin Info    Toxin GTx1-15 IC50
5 - 128 nM
[77- 81]
 Toxin Info    Toxin GTx1-15 IC50
5 - 128 nM
[14- 82]
 Toxin Info    Huwentoxin-IV IC50
10 - 150 nM
[14- 97]
 Toxin Info    Mu-theraphotoxin-Hhn1b 1 IC50
22.4 nM
[77- 104]
 Toxin Info    Mu-conotoxin KIIIB IC50
26 nM
[6- 18]
 Toxin Info    Kappa-actitoxin-Ael2a IC50
31 nM
[72- 110]
 Toxin Info    Mu-conotoxin BuIIIC IC50
34.1 nM
[8- 111]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
40 - 540 nM
[14- 126]
 Toxin Info    Beta/omega-theraphotoxin-Bp1a IC50
60 - 104 nM
[127]
 Toxin Info    Beta/omega-theraphotoxin-Tp1a IC50
60 - 104 nM
[77- 129]
 Toxin Info    Mu-theraphotoxin-Pspp1 IC50
73.7 nM
[93- 132]
 Toxin Info    Mu/omega-theraphotoxin-Tap1a IC50
81 - 301 nM
[133]
 Toxin Info    Mu/omega-theraphotoxin-Tap2a IC50
169 - 621 nM
[133]
 Toxin Info    Beta-theraphotoxin-Gr1a IC50
230 nM
[93- 135]
 Toxin Info    Hainantoxin-III 1 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 2 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 4 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 5 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 6 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 7 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 8 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 9 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 10 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 11 IC50
270 nM
[98- 136]
 Toxin Info    Hainantoxin-III 12 IC50
270 nM
[98- 136]
 Toxin Info    Mu-conotoxin SxIIIC IC50
363.8 nM
[137]
 Toxin Info    Mu/kappa-theraphotoxin-Ap1a IC50
519 nM
[138]
 Toxin Info    Beta-theraphotoxin-Gr1b IC50
600 nM
[93- 135]
 Toxin Info    Mu-conotoxin KIIIB IC50
875 nM
[6- 18]
 Toxin Info    Mu-conotoxin KIIIB IC50
1.37 μM
[6- 18]
 Toxin Info    Mu-thomitoxin-Hme1c IC50
1.447 μM
[139], [140]
 Toxin Info    Kappa-theraphotoxin-Aa1a IC50
1.449 μM
[138]
 Toxin Info    Beta/mu-theraphotoxin-Pe1b IC50
3.54 μM
[127]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
4.6 μM
[14- 126]
 Toxin Info    MuO-conotoxin MfVIA IC50
5.1 - 6.3 μM
[141], [142]
 Toxin Info    M-theraphotoxin-Gr1a IC50
7.4 - 14 μM
[77- 153]
 Toxin Info    Kappa-theraphotoxin-Gr2c IC50
12 μM
[81- 135]
References
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Ref 73 -Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity. J Biol Chem. 2014 Dec 19;289(51):35341-50. doi: 10.1074/jbc.M114.610436. Epub 2014 Oct 28.
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Ref 79 Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J Biol Chem. 2016 Jul 1;291(27):13974-13986. doi: 10.1074/jbc.M116.725978. Epub 2016 Apr 22.
Ref 80 Discovery and mode of action of a novel analgesic -toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.
Ref 81 Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 2011 Sep 1;58(3):265-76. doi: 10.1016/j.toxicon.2011.06.006. Epub 2011 Jun 28.
Ref 82 Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3):78. doi: 10.3390/toxins8030078.
Ref 83 cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena. Toxicon. 2003 Dec;42(7):715-23. doi: 10.1016/j.toxicon.2003.08.007.
Ref 84 Molecular diversification based on analysis of expressed sequence tags from the venom glands of the Chinese bird spider Ornithoctonus huwena. Toxicon. 2008 Jun 15;51(8):1479-89. doi: 10.1016/j.toxicon.2008.03.024. Epub 2008 Mar 27.
Ref 85 Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena. J Biol Chem. 2002 Dec 6;277(49):47564-71. doi: 10.1074/jbc.M204063200. Epub 2002 Sep 11.
Ref 86 Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel. PLoS One. 2013 Jun 24;8(6):e65984. doi: 10.1371/journal.pone.0065984. Print 2013.
Ref 87 Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration. J Biol Chem. 2008 Oct 3;283(40):27300-13. doi: 10.1074/jbc.M708447200. Epub 2008 Jul 14.
Ref 88 Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels. Toxicon. 2008 Feb;51(2):230-9. doi: 10.1016/j.toxicon.2007.09.008. Epub 2007 Sep 29.
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