Peptide Information

General Information of This Peptide
Peptide ID
BTDP006179
Peptide Name
Beta-toxin To4
Symonym
PT-beta* NaTx13.9; Toxin Tc54
Species
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Uniprot Name
SCX4_TITOB
Alphafold ID
P60215
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P60215
Sequence
MTRFVLFISCFFLIGMIVECKDGYLMEYGGCKMSCLMKKGTFCAEECTRMKGKDGYCYAW
LACYCYNMPDWVKIWNRATNKCGKRK
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Sequence Length
86
Mass (Da)
10084
Signal Sequence
MTRFVLFISCFFVIGMVVEC
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Sequence Removed Signal Peptide
KDGYLMEYGGCKMSCLMKKGTFCAEECTRMKGKDGYCYAWLACYCYNMPDWVKIWNRATN
KCGKRK
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Disulfide Bond
31-82;35-57;43-63;47-65
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 Inhibition rate
20-30 %
0.5 μM
 . [1- 5]
 Target Info    Nav1.2 Inhibition rate
40 - 50 %
0.5 μM
 . [1- 5]
 Target Info    Nav1.4 Inhibition rate
40 - 50 %
0.5 μM
 . [1- 5]
References
Ref 1 Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins. PLoS One. 2012;7(2):e30478. doi: 10.1371/journal.pone.0030478. Epub 2012 Feb 15.
Ref 2 Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One. 2018 Mar 21;13(3):e0193739. doi: 10.1371/journal.pone.0193739. eCollection 2018.
Ref 3 Scorpion toxins from Tityus cambridgei that affect Na(+)-channels. Toxicon. 2002 May;40(5):557-62. doi: 10.1016/s0041-0101(01)00252-5.
Ref 4 Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):55-66. doi: 10.1016/j.jchromb.2003.09.002.
Ref 5 To4, the first Tityus obscurus -toxin fully electrophysiologically characterized on human sodium channel isoforms. Peptides. 2017 Sep;95:106-115. doi: 10.1016/j.peptides.2017.07.010. Epub 2017 Jul 21.
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