Peptide Information

General Information of This Peptide
Peptide ID
BTDP001582
Peptide Name
Mu-theraphotoxin-Hd1a
Symonym
Mu-TRTX-Hd1a
Species
Cyriopagopus doriae (Tarantula spider) (Haplopelma doriae)
Uniprot Name
HD1A_CYRDO
Alphafold ID
A0A0J9X1W9
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MPQ
Sequence
ACLGFGKSCNPSNDQCCKSSSLACSTKHKWCKYEL
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Sequence Length
35
Mass (Da)
3828
Sequence Removed Signal Peptide
ACLGFGKSCNPSNDQCCKSSSLACSTKHKWCKYEL
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Disulfide Bond
2-17;9-24;16-31
PDB ID
2MPQ
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus doriae
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Inhibition rate
23 %
1 μM
 . [1]
 Target Info    Nav1.3 Inhibition rate
27 %
1 μM
 . [1]
 Target Info    Nav1.6 Inhibition rate
31 %
1 μM
 . [1]
 Target Info    Nav1.2 Inhibition rate
55 %
1 μM
 . [1]
 Target Info    Nav1.7 IC50
111 nM
 . . [1]
References
Ref 1 Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.
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