General Information of This Target
Target ID
BTDT10264
Target Name
Sodium channel protein type 4 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu-conotoxin GVIIJ Dissociation constant
4.7 nM
[1- 5]
 Toxin Info    Delta-conotoxin SVIE Dissociation constant
500 nM
[6], [7], [8], [9]
 Toxin Info    Mu-conotoxin KIIIB Dissociation constant
830 nM
[10- 22]
 Toxin Info    Venom peptide Sh41 Effect . [23]
 Toxin Info    Venom peptide Sh42 Effect . [23]
 Toxin Info    Toxin Acra3 Inhibition rate . [24], [25]
 Toxin Info    Beta-mammal toxin Css2 Inhibition rate . [26- 35]
 Toxin Info    Toxin Aah4 Inhibition rate . [36], [37], [38], [39]
 Toxin Info    Neurotoxic enhancer CSTX-13 Inhibition rate . [40], [41], [42], [43]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [44], [45]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [44], [45]
 Toxin Info    Delta-theraphotoxin-Hm1a Inhibition rate . [46], [47], [48], [49]
 Toxin Info    Mu-sparatoxin-Hv2 Inhibition rate
<10 %
[50]
 Toxin Info    Beta-mammal/insect toxin To1 Inhibition rate
20 %
[51- 55]
 Toxin Info    Mu-theraphotoxin-Hd1a Inhibition rate
23 %
[56]
 Toxin Info    Mu-theraphotoxin-Pspp1 Inhibition rate
35 %
[57], [58], [59], [60]
 Toxin Info    Beta-toxin To4 Inhibition rate
40 - 50 %
[51- 61]
 Toxin Info    Mu-conotoxin BuIIIC Inhibition rate
45 %
[12- 62]
 Toxin Info    Mu-conotoxin BuIIIC Inhibition rate
96 %
[12- 62]
 Toxin Info    Delta-conotoxin-like ErVIA Effective concentration 50
4.99 nM
[63]
 Toxin Info    Delta-conotoxin SuVIA Effective concentration 50
4.99 nM
[64]
 Toxin Info    Delta-buthitoxin-Hj1a Effective concentration 50
7.5 nM
[65]
 Toxin Info    Delta-actitoxin-Afv1b Effective concentration 50
30.62 nM
[66], [67], [68]
 Toxin Info    Delta-buthitoxin-Hj2a Effective concentration 50
32 nM
[65]
 Toxin Info    Delta-actitoxin-Avd1c Effective concentration 50
109.49 nM
[67- 73]
 Toxin Info    Alpha-like toxin BmK M1 Effective concentration 50
195 - 500 nM
[74- 87]
 Toxin Info    Alpha-toxin CvIV4 Effective concentration 50
530 nM
[88]
 Toxin Info    Delta-actitoxin-Bcs1a Effective concentration 50
820.84 nM
[67- 89]
 Toxin Info    Sodium channel neurotoxin MeuNaTxalpha-2 Effective concentration 50
2.23 μM
[90]
 Toxin Info    Delta-conotoxin-like CnVIB Effective concentration 50
2.3 μM
[91], [92]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
2.2 - 159 nM
[93- 99]
 Toxin Info    Mu-conotoxin KIIIB IC50
20 - 90 nM
[10- 22]
 Toxin Info    Beta-theraphotoxin-Ps1a IC50
20 - 610 nM
[100], [101], [102]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
30 - 39 nM
[18- 119]
 Toxin Info    MuO-conotoxin MfVIA IC50
81 nM
[120], [121]
 Toxin Info    Kappa-actitoxin-Ael2a IC50
92 nM
[68- 127]
 Toxin Info    Mu-thomitoxin-Hme1c IC50
103 nM
[128], [129]
 Toxin Info    Beta-theraphotoxin-Cm1b IC50
113 - 400 nM
[100- 130]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
263 - 888 nM
[100- 131]
 Toxin Info    Mu-conotoxin GIIIC IC50
286 nM
[132], [133]
 Toxin Info    Beta-theraphotoxin-Gr1b IC50
330 nM
[59- 134]
 Toxin Info    Mu-conotoxin KIIIB IC50
472 nM
[10- 22]
 Toxin Info    Mu-theraphotoxin-Pspp1 IC50
>2.1 μM
[57], [58], [59], [60]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
>3 μM
[100- 131]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
>3 μM
[100- 131]
 Toxin Info    Beta-theraphotoxin-Cd1a IC50
>30 μM
[130]
 Toxin Info    Toxin GTx1-15 IC50
0.2 - >10 μM
[101- 135]
 Toxin Info    Toxin GTx1-15 IC50
0.2 - >10 μM
[18- 136]
 Toxin Info    Beta-theraphotoxin-Gr1a IC50
1.29 μM
[59- 137]
 Toxin Info    Mu-conotoxin KIIIB IC50
2 μM
[10- 22]
 Toxin Info    Kappa-theraphotoxin-Gr2c IC50
4 μM
[59- 135]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
4.6 μM
[18- 119]
 Toxin Info    M-theraphotoxin-Gr1a IC50
7.4 - 14 μM
[101- 148]
References
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Ref 91 -Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity. J Biol Chem. 2014 Dec 19;289(51):35341-50. doi: 10.1074/jbc.M114.610436. Epub 2014 Oct 28.
Ref 92 Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. J Proteomics. 2009 Mar 6;72(2):210-8. doi: 10.1016/j.jprot.2009.01.019. Epub 2009 Jan 23.
Ref 93 Isolation and characterization of Jingzhaotoxin-V, a novel neurotoxin from the venom of the spider Chilobrachys jingzhao. Toxicon. 2007 Mar 1;49(3):388-99. doi: 10.1016/j.toxicon.2006.10.012. Epub 2006 Nov 6.
Ref 94 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 95 [Inhibition of Jingzhaotoxin-V on Kv4.3 channel]. Sheng Li Xue Bao. 2010 Jun 25;62(3):255-60.
Ref 96 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
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