Peptide Information

General Information of This Peptide
Peptide ID
BTDP008178
Peptide Name
Delta-conotoxin SVIE
Symonym
Omega-conotoxin SO-6; Omega-conotoxin-4
Species
Conus striatus (Striated cone)
Uniprot Name
O16E_CONST
Alphafold ID
Q9XZK5
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q9XZK5
Sequence
MKLTCVMIVAVLFLTTWTFVTADDSRYGLKNLFPKARHEMKNPEASKLNKRDGCSSGGTF
CGIHPGLCCSEFCFLWCITFID
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Sequence Length
82
Mass (Da)
9217
Signal Sequence
MKLTCVMIVAVLFLTTWTFVTA
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Sequence Removed Signal Peptide
DDSRYGLKNLFPKARHEMKNPEASKLNKRDGCSSGGTFCGIHPGLCCSEFCFLWCITFID
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Disulfide Bond
54-69;61-73;68-77
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Dissociation constant
500 nM
 . . [1], [2], [3], [4]
References
Ref 1 Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides. 1999;20(10):1139-44. doi: 10.1016/s0196-9781(99)00116-3.
Ref 2 Direct cDNA cloning of novel conopeptide precursors of the O-superfamily. Peptides. 2005 Mar;26(3):361-7. doi: 10.1016/j.peptides.2004.10.027.
Ref 3 Delta-conotoxin structure/function through a cladistic analysis. Biochemistry. 2001 Nov 6;40(44):13201-8. doi: 10.1021/bi010683a.
Ref 4 Molecular interaction of delta-conotoxins with voltage-gated sodium channels. FEBS Lett. 2005 Jul 18;579(18):3881-4. doi: 10.1016/j.febslet.2005.05.077.
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