Peptide Information

General Information of This Peptide
Peptide ID
BTDP003993
Peptide Name
Mu-conotoxin GIIIC
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CM3C_CONGE
Alphafold ID
P05482
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6MJD
Sequence
RDCCTPPKKCKDRRCKPLKCCA
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Sequence Length
22
Mass (Da)
2553
Sequence Removed Signal Peptide
RDCCTPPKKCKDRRCKPLKCCA
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Disulfide Bond
3-15;4-20;10-21
PDB ID
6MJD
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 IC50
286 nM
 . . [1], [2]
References
Ref 1 Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem. 1985 Aug 5;260(16):9280-8.
Ref 2 NMR Structure of -Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na(V) Channel Potency. Molecules. 2018 Oct 22;23(10):2715. doi: 10.3390/molecules23102715.
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