General Information of This Target
Target ID
BTDT10262
Target Name
Sodium channel protein type 3 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu-conotoxin GVIIJ Dissociation constant
15 nM
[1- 5]
 Toxin Info    Mu-thomitoxin-Hme1c Inhibition rate . [6], [7]
 Toxin Info    Beta-toxin Cll2 Inhibition rate . [8], [9], [10]
 Toxin Info    Toxin Acra3 Inhibition rate . [11], [12]
 Toxin Info    Beta-mammal toxin Css2 Inhibition rate . [9- 20]
 Toxin Info    Mu-sparatoxin-Hv2 Inhibition rate
<10 %
[21]
 Toxin Info    Mu-conotoxin BuIIIC Inhibition rate
10 %
[22], [23]
 Toxin Info    Beta-toxin Tf1a Inhibition rate
17 - 30 %
[24]
 Toxin Info    Mu-theraphotoxin-Hd1a Inhibition rate
27 %
[25]
 Toxin Info    Beta-mammal/insect toxin To1 Inhibition rate
80 %
[26- 30]
 Toxin Info    Delta-conotoxin-like ErVIA Effective concentration 50
3.98 nM
[31]
 Toxin Info    Delta-conotoxin SuVIA Effective concentration 50
3.98 nM
[32]
 Toxin Info    Delta-theraphotoxin-Hm1b Effective concentration 50
11.8 nM
[33], [34]
 Toxin Info    Beta/delta-theraphotoxin-Pre1a Effective concentration 50
45 nM
[35]
 Toxin Info    Delta-theraphotoxin-Hm1a Effective concentration 50
220 nM
[33- 37]
 Toxin Info    Delta-actitoxin-Afv1b Effective concentration 50
459.36 nM
[38], [39], [40]
 Toxin Info    Alpha-like toxin BmK M1 Effective concentration 50
565 nM
[41- 54]
 Toxin Info    Delta-actitoxin-Avd1c Effective concentration 50
759.22 nM
[39- 59]
 Toxin Info    Alpha-toxin CvIV4 Effective concentration 50
1.31 μM
[60]
 Toxin Info    Delta-actitoxin-Bcs1a Effective concentration 50
1.45842 μM
[39- 61]
 Toxin Info    Delta-conotoxin-like CnVID Effective concentration 50
1.7 μM
[62], [63]
 Toxin Info    Toxin GTx1-15 IC50
20.3 - 170 nM
[64], [65]
 Toxin Info    Toxin GTx1-15 IC50
20.3 - 170 nM
[66], [67]
 Toxin Info    Mu/omega-theraphotoxin-Tap1a IC50
81 - 301 nM
[68]
 Toxin Info    Mu-conotoxin SxIIIC IC50
89.4 nM
[69]
 Toxin Info    Kappa-actitoxin-Ael2a IC50
92 nM
[40- 75]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
102 nM
[18- 93]
 Toxin Info    Mu-theraphotoxin-Pspp1 IC50
201.5 nM
[89- 96]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
292 nM
[97- 103]
 Toxin Info    Hainantoxin-III 1 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 2 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 4 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 5 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 6 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 7 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 8 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 9 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 10 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 11 IC50
491 nM
[104], [105], [106]
 Toxin Info    Hainantoxin-III 12 IC50
491 nM
[104], [105], [106]
 Toxin Info    Beta-theraphotoxin-Gr1a IC50
770 nM
[89- 108]
 Toxin Info    Beta-theraphotoxin-Cd1a IC50
>30 μM
[109]
 Toxin Info    Beta-theraphotoxin-Cm1b IC50
0.088 - 5.570 μM
[65- 110]
 Toxin Info    Mu/omega-theraphotoxin-Tap2a IC50
1.216 μM
[68]
 Toxin Info    Beta-theraphotoxin-Gr1b IC50
1.28 μM
[89- 108]
 Toxin Info    MuO-conotoxin MfVIA IC50
2.2 μM
[111], [112]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
4.6 μM
[18- 93]
 Toxin Info    M-theraphotoxin-Gr1a IC50
7.4 - 14 μM
[64- 123]
 Toxin Info    Mu-theraphotoxin-Cg1a IC50
7.95 μM
[98- 125]
 Toxin Info    Beta/delta-theraphotoxin-Pre1a IC50
8 μM
[35]
 Toxin Info    Kappa-theraphotoxin-Gr2c IC50
24 μM
[64- 108]
References
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Ref 86 High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots. Int J Pept. 2015;2015:537508. doi: 10.1155/2015/537508. Epub 2015 Dec 30.
Ref 87 Binary architecture of the Nav1.2-2 signaling complex. Elife. 2016 Feb 19;5:e10960. doi: 10.7554/eLife.10960.
Ref 88 Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor. Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662.
Ref 89 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 90 Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. J Med Chem. 2014 Aug 14;57(15):6623-31. doi: 10.1021/jm500687u. Epub 2014 Jul 24.
Ref 91 Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.
Ref 92 Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17.
Ref 93 Structures of human Na(v)1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 Mar 22;363(6433):1303-1308. doi: 10.1126/science.aaw2493. Epub 2019 Feb 14.
Ref 94 Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883.
Ref 95 Corrigendum: Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816.
Ref 96 Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel). 2019 Aug 22;11(9):484. doi: 10.3390/toxins11090484.
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