Peptide Information

General Information of This Peptide
Peptide ID
BTDP008645
Peptide Name
Delta-theraphotoxin-Hm1b
Species
Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
Uniprot Name
TX1B_HETMC
Alphafold ID
P0DOC5
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6V6T
Sequence
ECRYLFGGCKTTADCCKHLGCRTDLYYCAWDGTF
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Sequence Length
34
Mass (Da)
3901
Sequence Removed Signal Peptide
ECRYLFGGCKTTADCCKHLGCRTDLYYCAWDGTF
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Disulfide Bond
2-16;9-21;15-28
PDB ID
6V6T
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Heteroscodra
Species: Heteroscodra maculata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Modifier
 [1], [2]
 Target Info    Nav1.1 Effective concentration 50
11.6 nM
 .
Delay fast inactivation of the channel
 [1], [2]
 Target Info    Nav1.3 Effective concentration 50
11.8 nM
 .
Delay fast inactivation of the channel
 [1], [2]
References
Ref 1 Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.
Ref 2 A selective Na(V)1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol. 2020 Nov;181:113991. doi: 10.1016/j.bcp.2020.113991. Epub 2020 Apr 23.
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