Peptide Information

General Information of This Peptide
Peptide ID
BTDP008431
Peptide Name
Mu-theraphotoxin-Cg1a
Symonym
Jingzhaotoxin-34; Peptide F6-25.51
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZT34_CHIGU
Alphafold ID
B1P1F7
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B1P1F7
Sequence
MKVLVLITLAVLGAMFVWTSAAELEERGSDQRDSPAWVKSMERIFQSEERACREWLGGCS
KDADCCAHLECRKKWPYHCVWDWTVRK
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Sequence Length
87
Mass (Da)
10136
Signal Sequence
MKVLVLITLAVLGAMFVWTSA
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Sequence Removed Signal Peptide
AELEERGSDQRDSPAWVKSMERIFQSEERACREWLGGCSKDADCCAHLECRKKWPYHCVW
DWTVRK
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Disulfide Bond
52-66;59-71;65-79
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Inhibition rate .
100 μM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv Inhibition rate
22 %
1 μM
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.7 IC50
610 nM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.3 IC50
7.95 μM
 .
Modifier
 [1], [2], [3], [4]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Expression and characterization of jingzhaotoxin-34, a novel neurotoxin from the venom of the tarantula Chilobrachys jingzhao. Peptides. 2009 Jun;30(6):1042-8. doi: 10.1016/j.peptides.2009.02.018. Epub 2009 Mar 13.
Ref 4 Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain. Toxins (Basel). 2018 Feb 2;10(2):64. doi: 10.3390/toxins10020064.
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