Target Information

General Information of This Target
Target ID
BTDT10198
Target Name
Potassium voltage-gated channel subfamily B member 1
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Kappa-theraphotoxin-Gr1b . . [1]
 Toxin Info    Kappa-theraphotoxin-Pg2a . . [2]
 Toxin Info    SgTx-I (D24A) Dissociation constant
140 nM
 [3]
 Toxin Info    Beta/kappa-theraphotoxin-Cg1a Dissociation constant
430 nM
 [4- 8]
 Toxin Info    SgTx-I (D14A) Dissociation constant
450 nM
 [3]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Dissociation constant
760 nM
 [6- 10]
 Toxin Info    SgTx-I (S23A) Dissociation constant
1.4 μM
 [3]
 Toxin Info    SgTx-I (G25A) Dissociation constant
1.5 μM
 [3]
 Toxin Info    SgTx-I (K17A) Dissociation constant
1.6 μM
 [3]
 Toxin Info    SgTx-I (G8A) Dissociation constant
1.9 μM
 [3]
 Toxin Info    SgTx-I (A13S) Dissociation constant
2.4 μM
 [3]
 Toxin Info    SgTx-I (T1A) Dissociation constant
2.6 μM
 [3]
 Toxin Info    Kappa-theraphotoxin-Scg1a Dissociation constant
2.7 μM
 [3- 16]
 Toxin Info    Kappa-theraphotoxin-Scg1a Dissociation constant
2.7 μM
 [3- 16]
 Toxin Info    U18-theraphotoxin-Cg1a Dissociation constant
3.3 μM
 [5- 17]
 Toxin Info    SgTx-I (T12A) Dissociation constant
4 μM
 [3]
 Toxin Info    SgTx-I (K10A) Dissociation constant
5.2 μM
 [3]
 Toxin Info    SgTx-I (T11A) Dissociation constant
6.3 μM
 [3]
 Toxin Info    SgTx-I (K26A) Dissociation constant
6.7 μM
 [3]
 Toxin Info    SgTx-I (A20S) Dissociation constant
8.3 μM
 [3]
 Toxin Info    SgTx-I (F34A) Dissociation constant
9.4 μM
 [3]
 Toxin Info    SgTx-I (G32A) Dissociation constant
9.6 μM
 [3]
 Toxin Info    SgTx-I (G7A) Dissociation constant
10 μM
 [3]
 Toxin Info    SgTx-I (T33A) Dissociation constant
10 μM
 [3]
 Toxin Info    Delta-theraphotoxin-Cg1a 1 Dissociation constant
12.2 μM
 [6- 22]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a Dissociation constant
14.3 μM
 [5- 25]
 Toxin Info    SgTx-I (A29S) Dissociation constant
20 μM
 [3]
 Toxin Info    SgTx-I (H18A) Dissociation constant
20 μM
 [3]
 Toxin Info    SgTx-I (Y4A) Dissociation constant
20 μM
 [3]
 Toxin Info    SgTx-I (D31A) Dissociation constant
30 μM
 [3]
 Toxin Info    Potassium channel toxin alpha-KTx 1.1 Inhibition constant
>2 μM
 [26- 46]
 Toxin Info    Potassium channel toxin alpha-KTx 3.2 Inhibition constant
>2 μM
 [32- 48]
 Toxin Info    Potassium channel toxin alpha-KTx 3.4 Inhibition constant
>2 μM
 [32- 49]
 Toxin Info    Venom peptide Sh41 Effect . [50]
 Toxin Info    Venom peptide Sh42 Effect . [50]
 Toxin Info    U-scoloptoxin(15)-Sm2a Effect . [51], [52]
 Toxin Info    Defensin, beta 1 Inhibition rate . [53]
 Toxin Info    Potassium channel toxin alpha-KTx 6 hetlaxin Inhibition rate . [54]
 Toxin Info    Mu-thomitoxin-Hme1c Inhibition rate . [55], [56]
 Toxin Info    Neurotoxic enhancer CSTX-13 Inhibition rate . [57], [58], [59], [60]
 Toxin Info    Toxin PhcrTx2 Inhibition rate . [61]
 Toxin Info    Alpha/kappa-conotoxin pl14a Inhibition rate . [62]
 Toxin Info    Peptide F5-20.38 Inhibition rate . [53]
 Toxin Info    Delta/kappa-actitoxin-Avd4a Inhibition rate . [63- 68]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [69], [70]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [69], [70]
 Toxin Info    Potassium channel toxin gamma-KTx 2.1 Inhibition rate . [34- 79]
 Toxin Info    Potassium channel toxin gamma-KTx 2.1 Inhibition rate . [34- 79]
 Toxin Info    Mu-scoloptoxin(15)-Ssm1a Inhibition rate . [80]
 Toxin Info    Peptide F5-20.38 (V33A,A34E) Inhibition rate . [53]
 Toxin Info    SgTx-I (L5A) Inhibition rate . [3]
 Toxin Info    SgTx-I (R22A) Inhibition rate . [3]
 Toxin Info    SgTx-I (R3A) Inhibition rate . [3]
 Toxin Info    Kappa-actitoxin-Ael2a Inhibition rate . [66- 85]
 Toxin Info    Potassium channel toxin kappa-KTx 1.2 Inhibition rate . [86- 90]
 Toxin Info    Kappa-theraphotoxin-Ps1a Inhibition rate
6 %
 [91], [92], [93]
 Toxin Info    Kappa-theraphotoxin-Ps1b Inhibition rate
8 %
 [91]
 Toxin Info    Tau-theraphotoxin-Pc1c Inhibition rate
8.2 %
 [94]
 Toxin Info    Kappa-theraphotoxin-Cg2a Inhibition rate
9 %
 [5- 95]
 Toxin Info    Kappa-theraphotoxin-Hm2a Inhibition rate
18 %
 [96]
 Toxin Info    Delta-theraphotoxin-Hm1a Inhibition rate
23 %
 [96], [97], [98], [99]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a Inhibition rate
35 %
 [5- 25]
 Toxin Info    Tau-theraphotoxin-Pc1b Inhibition rate
41.4 %
 [94]
 Toxin Info    U21-theraphotoxin-Cg1b Inhibition rate
80 %
 [5], [6]
 Toxin Info    Beta/kappa-theraphotoxin-Cg1a Inhibition rate
95 %
 [4- 8]
 Toxin Info    Kappa-theraphotoxin-Cg1a 6 Inhibition rate
100 %
 [5- 10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 3 Inhibition rate
100 %
 [5- 10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 2 Inhibition rate
100 %
 [5- 10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 4 Inhibition rate
100 %
 [5- 10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 5 Inhibition rate
100 %
 [5- 10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Inhibition rate
100 %
 [6- 10]
 Toxin Info    Kappa-theraphotoxin-Pg1a IC50
5.1 nM
 [2- 102]
 Toxin Info    Kappa-theraphotoxin-Sc1a IC50
12.7 nM
 [96]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
14.3 nM
 [5- 103]
 Toxin Info    Beta/omega-theraphotoxin-Bp1a IC50
411 nM
 [104]
 Toxin Info    Beta/omega-theraphotoxin-Tp1a IC50
411 nM
 [15- 111]
 Toxin Info    U21-theraphotoxin-Cg1b IC50
470 nM
 [5], [6]
 Toxin Info    Beta/kappa-theraphotoxin-Cg1a IC50
710 nM
 [4- 8]
 Toxin Info    Delta/kappa-theraphotoxin-Pm1a IC50
0.43 μM
 [112]
 Toxin Info    Tau/kappa-theraphotoxin-Pc1a IC50
7.4 μM
 [94]
 Toxin Info    Delta-theraphotoxin-Cg1a 1 IC50
8.05 μM
 [6- 22]
References
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Ref 80 Centipedes subdue giant prey by blocking KCNQ channels. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1646-1651. doi: 10.1073/pnas.1714760115. Epub 2018 Jan 22.
Ref 81 APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels. Mol Pharmacol. 2003 Jul;64(1):59-69. doi: 10.1124/mol.64.1.59.
Ref 82 APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-a-go-go- related potassium channel. Mol Pharmacol. 2007 Aug;72(2):259-68. doi: 10.1124/mol.107.035840. Epub 2007 May 1.
Ref 83 A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. 2012 Dec;26(12):5141-51. doi: 10.1096/fj.12-218479. Epub 2012 Sep 12.
Ref 84 Defensin-neurotoxin dyad in a basally branching metazoan sea anemone. FEBS J. 2017 Oct;284(19):3320-3338. doi: 10.1111/febs.14194. Epub 2017 Sep 6.
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