Peptide Information

General Information of This Peptide
Peptide ID
BTDP008577
Peptide Name
U18-theraphotoxin-Cg1a
Symonym
Jingzhaotoxin-32; Jingzhaotoxin-9; Jingzhaotoxin-IX; Peptide F6-16.24
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZT32_CHIGU
Alphafold ID
B1P1F5
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B1P1F5
Sequence
KASVLITLAVLGVMFVWTSAAELEERGSDQRDSPALIKSMAKVFQSEERECTKLLGGCTK
DSECCPHLGCRKKWPYHCGWDGTFGK
   Click to Show/Hide
Sequence Length
86
Mass (Da)
9524
Sequence Removed Signal Peptide
ECTKLLGGCTKDSECCPHLGCRKKWPYHCGWDGTF
   Click to Show/Hide
Disulfide Bond
51-65;58-70;64-78
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
3.3 μM
 .
Modifier
 [1], [2], [3]
 Target Info    Kv1.1 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv2.1 IC50
604 nM
 .
TTX-sensitive sodium currents
[1], [2], [3]
 Target Info    Nav1.5 IC50
0.45 μM
 . . [1], [2], [3]
 Target Info    DRG neuron IC50
0.6 μM
 .
TTX-sensitive sodium currents
[1], [2], [3]
 Target Info    DRG neuron IC50
0.95 μM
 .
TTX-insensitive sodium currents
[1], [2], [3]
 Target Info    Nav1.4 IC50
5.42 μM
 . . [1], [2], [3]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Jingzhaotoxin-IX, a novel gating modifier of both sodium and potassium channels from Chinese tarantula Chilobrachys jingzhao. Neuropharmacology. 2009 Aug;57(2):77-87. doi: 10.1016/j.neuropharm.2009.04.009. Epub 2009 May 4.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.