Peptide Information

General Information of This Peptide
Peptide ID
BTDP008657
Peptide Name
Potassium channel toxin alpha-KTx 3.4
Symonym
Agitoxin-1; Leiurotoxin II; Leiurotoxin-2
Species
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Uniprot Name
KAX34_LEIHE
Alphafold ID
P46110
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P46110
Sequence
GVPINVKCTGSPQCLKPCKDAGMRFGKCINGKCHCTPK
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Sequence Length
38
Mass (Da)
4021
Sequence Removed Signal Peptide
GVPINVKCTGSPQCLKPCKDAGMRFGKCINGKCHCTPK
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Disulfide Bond
8-28;14-33;18-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Leiurus
Species: Leiurus quinquestriatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker potassium channel Inhibition constant
0.16 nM
 .
Blocker
 [1], [2]
 Target Info    Shaker Inhibition constant
0.16 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition constant
1.7 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 Inhibition constant
1.7 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 Inhibition constant
3.5 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 Inhibition constant
4.5 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.1 Inhibition constant
136 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1 Inhibition constant
136 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.6 Inhibition constant
149 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.6 Inhibition constant
149 nM
 .
Blocker
 [1], [2]
 Target Info    Kv2.1 Inhibition constant
>2 μM
 .
Blocker
 [1], [2]
 Target Info    Kir1.1 Inhibition rate .
2.5 μM
Blocker
 [3]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1], [2]
 Target Info    Kv1 Inhibition rate .
100 nM
Blocker
 [4]
 Target Info    Kv2.1 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv1.2 IC50
9 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 IC50
12 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1 IC50
15 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2-1.2-1.2-1.2 IC50
17 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 IC50
20 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2-1.2-1.2-1.2 IC50
26 nM
 .
Blocker
 [1], [2]
References
Ref 1 Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 1994 Jun 7;33(22):6834-9. doi: 10.1021/bi00188a012.
Ref 2 Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones). Toxicon. 2006 May;47(6):628-39. doi: 10.1016/j.toxicon.2006.01.015. Epub 2006 Mar 23.
Ref 3 Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 1997 Jun 10;36(23):6936-40. doi: 10.1021/bi9702849.
Ref 4 Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol. 2010 Sep;136(3):273-82. doi: 10.1085/jgp.200910398.
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