Peptide Information

General Information of This Peptide
Peptide ID
BTDP008579
Peptide Name
U21-theraphotoxin-Cg1b
Symonym
Jingzhaotoxin-39; Peptide F4-28.01
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZT39_CHIGU
Alphafold ID
B1P1G4
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B1P1G4
Sequence
MKVSVLITLAVLGVMFLLTSAEERGSDQMDSPAWLKSMERIFQSEERECRWLFGGCEKDS
DCCEHLGCRRAKPSWCGWDFTFGK
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Sequence Length
84
Mass (Da)
9628
Signal Sequence
MKVSVLITLAVLGVMFLLTSA
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Sequence Removed Signal Peptide
EERGSDQMDSPAWLKSMERIFQSEERECRWLFGGCEKDSDCCEHLGCRRAKPSWCGWDFT
FGK
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Disulfide Bond
49-63;56-68;62-76
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
100 μM
Blocker
 [1], [2]
 Target Info    Kv1.2 Inhibition rate .
100 μM
Blocker
 [1], [2]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [1], [2]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Blocker
 [1], [2]
 Target Info    Kv3.1 Inhibition rate .
100 μM
Blocker
 [1], [2]
 Target Info    Kv4.2 Inhibition rate
53 %
5 μM
Blocker
 [1], [2]
 Target Info    Kv4.1 Inhibition rate
62 %
5 μM
Blocker
 [1], [2]
 Target Info    Kv2.1 Inhibition rate
80 %
5 μM
Blocker
 [1], [2]
 Target Info    Kv2.1 IC50
470 nM
 .
Blocker
 [1], [2]
 Target Info    Kv11 IC50
612.6 nM
 .
Blocker
 [3]
 Target Info    Kv4.1 IC50
1.17 μM
 .
Blocker
 [1], [2]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Effects and mechanism of gating modifier spider toxins on the hERG channel. Toxicon. 2021 Jan 15;189:56-64. doi: 10.1016/j.toxicon.2020.11.008. Epub 2020 Nov 17.
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