Peptide Information

General Information of This Peptide
Peptide ID
BTDP008398
Peptide Name
Kappa-theraphotoxin-Ps1b
Symonym
PaTX2; Phrixotoxin-2
Species
Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Uniprot Name
TXP2_PARSR
Alphafold ID
P61231
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P61231
Sequence
YCQKWMWTCDEERKCCEGLVCRLWCKRIINM
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Sequence Length
31
Mass (Da)
3929
Sequence Removed Signal Peptide
YCQKWMWTCDEERKCCEGLVCRLWCKRIINM
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Disulfide Bond
2-16;9-21;15-25
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Paraphysa
Species: Paraphysa scrofa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kir2.1 Inhibition rate .
1 μM
 . [1]
 Target Info    K2p2.1 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv1.1 Inhibition rate .
5 μM
 . [1]
 Target Info    Kv1.2 Inhibition rate .
5 μM
 . [1]
 Target Info    Kv1.3 Inhibition rate .
5 μM
 . [1]
 Target Info    Kv1.4 Inhibition rate .
5 μM
 . [1]
 Target Info    Kv1.5 Inhibition rate .
5 μM
 . [1]
 Target Info    Kv3.1 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv3.2 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv3.4 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv2.1 Inhibition rate
8 %
500 nM
 . [1]
 Target Info    Kv2.2 Inhibition rate
11 %
500 nM
 . [1]
 Target Info    Kv4.2 IC50
34 nM
 . . [1]
 Target Info    Kv4.2 IC50
34 nM
 .
Block the neuronal TTX-sensitive sodium currents of neuroblastoma cells
 [1]
 Target Info    Kv4.3 IC50
71 nM
 . . [1]
 Target Info    Kv4.3 IC50
71 nM
 .
Block the neuronal TTX-sensitive sodium currents of neuroblastoma cells
 [1]
References
Ref 1 Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol. 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283.
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