Peptide Information

General Information of This Peptide
Peptide ID
BTDP008371
Peptide Name
Delta-theraphotoxin-Cg1a 1
Symonym
Jingzhaotoxin-1; Jingzhaotoxin-I; Peptide F5-24.92
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZT1A_CHIGU
Alphafold ID
P83974
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P83974
Sequence
MKTSILFVIFSLALLFALSAATEIEETDRACGQFWWKCGEGKPPCCANFACKIGLYLCIW
SP
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Sequence Length
62
Mass (Da)
6894
Signal Sequence
MKTSILFVIFSLALLFALSAA
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Sequence Removed Signal Peptide
TEIEETDRACGQFWWKCGEGKPPCCANFACKIGLYLCIWSP
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Disulfide Bond
31-46;38-51;45-58
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
12.2 μM
 .
Modifier
 [1- 7]
 Target Info    Kv1.1 Inhibition rate .
1 μM
Modifier
 [1- 7]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Modifier
 [1- 7]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Modifier
 [1- 7]
 Target Info    Nav1.5 IC50
335 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.4 IC50
339 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.7 IC50
348 nM
 .
Modifier
 [1- 7]
 Target Info    Kv11 IC50
626.9 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.3 IC50
845 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.2 IC50
870 nM
 .
Modifier
 [1- 7]
 Target Info    Kv2.1 IC50
8.05 μM
 .
Modifier
 [1- 7]
References
Ref 1 Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation. J Biol Chem. 2005 Apr 1;280(13):12069-76. doi: 10.1074/jbc.M411651200. Epub 2004 Nov 17.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
Ref 4 Characterization of the excitatory mechanism induced by Jingzhaotoxin-I inhibiting sodium channel inactivation. Toxicon. 2007 Sep 15;50(4):507-17. doi: 10.1016/j.toxicon.2007.04.018. Epub 2007 May 3.
Ref 5 Molecular determinants for the tarantula toxin jingzhaotoxin-I interacting with potassium channel Kv2.1. Toxicon. 2013 Mar 1;63:129-36. doi: 10.1016/j.toxicon.2012.12.001. Epub 2012 Dec 13.
Ref 6 Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels. Toxicon. 2016 Mar 1;111:13-21. doi: 10.1016/j.toxicon.2015.12.009. Epub 2015 Dec 23.
Ref 7 Sequence-specific assignment of 1H-NMR resonance and determination of the secondary structure of Jingzhaotoxin-I. Acta Biochim Biophys Sin (Shanghai). 2005 Aug;37(8):567-72. doi: 10.1111/j.1745-7270.2005.00078.x.
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