Peptide Information

General Information of This Peptide
Peptide ID
BTDP008658
Peptide Name
Potassium channel toxin alpha-KTx 3.2
Symonym
Agitoxin-2
Species
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Uniprot Name
KAX32_LEIHE
Alphafold ID
P46111
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1AGT
Sequence
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
   Click to Show/Hide
Sequence Length
38
Mass (Da)
4097
Sequence Removed Signal Peptide
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
   Click to Show/Hide
Disulfide Bond
8-28;14-33;18-35
PDB ID
1AGT
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Leiurus
Species: Leiurus quinquestriatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Dissociation constant
3.4 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.1 Inhibition constant
<1 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.3 Inhibition constant
<1 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.6 Inhibition constant
<1 nM
 .
Blocker
 [1- 5]
 Target Info    Shaker potassium channel Inhibition constant
<1 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.6 Inhibition constant
0.037 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1 Inhibition constant
0.044 nM
 .
Blocker
 [1- 5]
 Target Info    Shaker Inhibition constant
0.64 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition constant
4 nM
 .
Blocker
 [1- 5]
 Target Info    Kv2.1 Inhibition constant
>2 μM
 .
Blocker
 [1- 5]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1- 5]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [6]
 Target Info    Kv2.1 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [6]
 Target Info    Kir1.1 Inhibition rate .
2.5 μM
Blocker
 [7]
 Target Info    Kv1.2 Inhibition rate
100 %
500 nM
Blocker
 [6]
 Target Info    Kv1 IC50
2 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.3 IC50
9 nM
 .
Blocker
 [6]
 Target Info    Kv1.2 IC50
26.8 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.6 IC50
92 nM
 .
Blocker
 [1- 5]
 Target Info    KCa3.1 IC50
1.152 μM
 .
Blocker
 [1- 5]
References
Ref 1 Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 1994 Jun 7;33(22):6834-9. doi: 10.1021/bi00188a012.
Ref 2 Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins. Protein Sci. 2008 Jan;17(1):107-18. doi: 10.1110/ps.073122908. Epub 2007 Nov 27.
Ref 3 A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22211-6. doi: 10.1073/pnas.0910123106. Epub 2009 Dec 10.
Ref 4 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 5 Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Protein Sci. 1995 Aug;4(8):1478-89. doi: 10.1002/pro.5560040805.
Ref 6 Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels. Sci Rep. 2016 Sep 21;6:33314. doi: 10.1038/srep33314.
Ref 7 Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 1997 Jun 10;36(23):6936-40. doi: 10.1021/bi9702849.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.