Peptide Information

General Information of This Peptide
Peptide ID
BTDP008680
Peptide Name
Kappa-theraphotoxin-Sc1a
Symonym
Stromatoxin-1
Species
Stromatopelma calceatum (Featherleg baboon tarantula) (Scodra calceata)
Uniprot Name
TX1_STRCF
Alphafold ID
P60991
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P60991
Sequence
DCTRMFGACRRDSDCCPHLGCKPTSKYCAWDGTI
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Sequence Length
34
Mass (Da)
3798
Sequence Removed Signal Peptide
DCTRMFGACRRDSDCCPHLGCKPTSKYCAWDGTI
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Disulfide Bond
2-16;9-21;15-28
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Stromatopelma
Species: Stromatopelma calceatum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv4.1 Inhibition rate .
100 nM
Modifier
 [1]
 Target Info    Kv1.5 Inhibition rate .
300 nM
Modifier
 [1]
 Target Info    Kv1.6 Inhibition rate .
300 nM
Modifier
 [1]
 Target Info    Kv4.3 Inhibition rate .
100 nM
Modifier
 [1]
 Target Info    Kv1.4 Inhibition rate
4 %
400 nM
Modifier
 [1]
 Target Info    Kv3.4 Inhibition rate
4 %
300 nM
Modifier
 [1]
 Target Info    Kv1.1 Inhibition rate
8 %
300 nM
Modifier
 [1]
 Target Info    Kv1.3 Inhibition rate
9 %
300 nM
Modifier
 [1]
 Target Info    Kv1.2 Inhibition rate
10 %
300 nM
Modifier
 [1]
 Target Info    Kv7.1 Inhibition rate
19 %
300 nM
Modifier
 [1]
 Target Info    Kv4.2 IC50
1.2 nM
 .
Modifier
 [1]
 Target Info    Kv4.2 IC50
1.2 nM
 .
Modifier
 [1]
 Target Info    Kv2.1/9.3 IC50
7.2 nM
 .
Modifier
 [1]
 Target Info    Kv2.1/Kv9.3 IC50
7.2 nM
 .
Modifier
 [1]
 Target Info    Kv2.1 IC50
12.7 nM
 .
Modifier
 [1]
 Target Info    Kv2.1 IC50
12.7 nM
 .
Modifier
 [1]
 Target Info    Kv2.2 IC50
21.4 nM
 .
Modifier
 [1]
 Target Info    Kv2.2 IC50
21.4 nM
 .
Modifier
 [1]
References
Ref 1 Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol. 2002 Jul;62(1):48-57. doi: 10.1124/mol.62.1.48.
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