Peptide Information

General Information of This Peptide
Peptide ID
BTDP008714
Peptide Name
Alpha/kappa-conotoxin pl14a
Symonym
Conotoxin PlXIVA
Species
Conus planorbis (Planorbis cone)
Uniprot Name
CJEA_CONPO
Alphafold ID
Q0N4U8
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2FQC
Sequence
MPSVRSVTCCCLLWMMFSVQLVTPGSPGTAQLSGHRTARFPRPRICNLACRAGIGHKYPF
CHCRGKRDAVSSSMAV
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Sequence Length
76
Mass (Da)
8298
Sequence Removed Signal Peptide
FPRPRICNLACRAGIGHKYPFCHCR
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Disulfide Bond
46-61;50-63
PDB ID
2FQC , 2NAV , 2NAW
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus planorbis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv1.3 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv1.4 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
 . [1]
 Target Info    Kv2.1 Inhibition rate .
2 μM
 . [1]
 Target Info    Kv3.4 Inhibition rate .
2 μM
 . [1]
 Target Info    Kv1.1 Inhibition rate
5 %
1 μM
 . [1]
 Target Info    nAChR alpha-1-beta-1-epsilon-delta IC50
0.54 μM
 . . [1]
 Target Info    Kv1.6 IC50
1.59 μM
 . . [1]
 Target Info    Kv1.6 IC50
1.59 μM
 . . [1]
 Target Info    nAChR alpha-3/beta-4 IC50
8.7 μM
 .
Neuronal
 [1]
References
Ref 1 A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry. 2006 Jul 11;45(27):8331-40. doi: 10.1021/bi060263r.
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