Peptide Information

General Information of This Peptide
Peptide ID
BTDP008700
Peptide Name
Kappa-theraphotoxin-Pg1a
Symonym
Guangxitoxin-1E
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
TXG1E_CHIGU
Alphafold ID
P84835
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2WH9
Sequence
EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP
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Sequence Length
36
Mass (Da)
3955
Sequence Removed Signal Peptide
EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP
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Disulfide Bond
4-19;11-24;18-31
PDB ID
2WH9
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.3 Dissociation constant
2.6 nM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv2.1 Dissociation constant
5.1 nM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv4.3 Dissociation constant
54 nM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.2 Inhibition rate .
4 μM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.3 Inhibition rate .
4 μM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.5 Inhibition rate .
4 μM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv3.2 Inhibition rate .
4 μM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv2.1 IC50
5.1 nM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv4.3 IC50
39 nM
 .
Modifier
 [1], [2], [3], [4]
References
Ref 1 Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55(4):1034-42. doi: 10.2337/diabetes.55.04.06.db05-0788.
Ref 2 Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon. 2007 Feb;49(2):231-8. doi: 10.1016/j.toxicon.2006.09.012. Epub 2006 Sep 23.
Ref 3 A KV2.1 gating modifier binding assay suitable for high throughput screening. Channels (Austin). 2009 Nov;3(6):437-47. doi: 10.4161/chan.3.6.10201.
Ref 4 Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels. Biochemistry. 2010 Jun 29;49(25):5134-42. doi: 10.1021/bi100246u.
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