Peptide Information

General Information of This Peptide
Peptide ID
BTDP008570
Peptide Name
Mu-scoloptoxin(15)-Ssm1a
Symonym
Potassium channel toxin SsTx; Ssm spooky toxin
Species
Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Uniprot Name
TXF1A_SCOMU
Alphafold ID
A0A2L0ART2
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5X0S
Sequence
MEKKIIFLVFLVALLALPGFISTEVIKKDTPYKKRKFPYKSECLKACATSFTGGDESRIQ
EGKPGFFKCTCYFTTG
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Sequence Length
76
Mass (Da)
8568
Signal Sequence
MEKKIIFLVFLVALLALPGFIST
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Sequence Removed Signal Peptide
EVIKKDTPYKKRKFPYKSECLKACATSFTGGDESRIQEGKPGFFKCTCYFTTG
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Disulfide Bond
43-69;47-71
PDB ID
5X0S
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Chilopoda
Order: Scolopendromorpha
Family: Scolopendridae
Genus: Scolopendra
Species: Scolopendra mutilans
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kir6.2 Dissociation constant
180 nM
 . . [1]
 Target Info    Kv2.1 Inhibition rate .
100 μM
 . [1]
 Target Info    Kv4.1 Inhibition rate .
100 μM
 . [1]
 Target Info    Kv11 Inhibition rate .
100 μM
 . [1]
 Target Info    KCa1.1 Inhibition rate .
100 μM
 . [1]
 Target Info    Kv7.4 IC50
2.5 μM
 . . [1]
 Target Info    Kv7.4 IC50
2.5 μM
 . . [1]
 Target Info    Kv7.2 IC50
2.7 μM
 . . [1]
 Target Info    Kv7.2 IC50
2.7 μM
 . . [1]
 Target Info    Kv7.5 IC50
2.7 μM
 . . [1]
 Target Info    Kv7.5 IC50
2.7 μM
 . . [1]
 Target Info    Kv7.1 IC50
2.8 μM
 . . [1]
 Target Info    Kv7.1 IC50
2.8 μM
 . . [1]
References
Ref 1 Centipedes subdue giant prey by blocking KCNQ channels. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1646-1651. doi: 10.1073/pnas.1714760115. Epub 2018 Jan 22.
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