Peptide Information

General Information of This Peptide
Peptide ID
BTDP008393
Peptide Name
Kappa-theraphotoxin-Cg2a
Symonym
Jingzhaotoxin-12; Jingzhaotoxin-45; Jingzhaotoxin-XII; Peptide F4-20.99
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZT45_CHIGU
Alphafold ID
P0C5X7
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C5X7
Sequence
MKGSAFAIILGLVVLCACSFAEDEQDQFASPNELLRSMFLESRHELIPEVEGRYCQKWMW
TCDSERKCCEGYVCELWCKYNLG
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Sequence Length
83
Mass (Da)
9610
Signal Sequence
MKGSAFAIILGLVVLCACSFA
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Sequence Removed Signal Peptide
EDEQDQFASPNELLRSMFLESRHELIPEVEGRYCQKWMWTCDSERKCCEGYVCELWCKYN
LG
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Disulfide Bond
55-69;62-74;68-78
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv3.1 Inhibition rate .
100 μM
Modifier
 [1], [2], [3]
 Target Info    Kv2.1 Inhibition rate
9 %
1 μM
Modifier
 [1], [2], [3]
 Target Info    Kv4.2 Inhibition rate
15 %
1 μM
Modifier
 [1], [2], [3]
 Target Info    Kv4.1 IC50
363 nM
 .
Modifier
 [1], [2], [3]
References
Ref 1 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007 Oct;50(5):646-52. doi: 10.1016/j.toxicon.2007.05.009. Epub 2007 Jun 3.
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