Peptide Information

General Information of This Peptide
Peptide ID
BTDP008682
Peptide Name
Kappa-theraphotoxin-Hm2a
Symonym
Heteroscodratoxin-2
Species
Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
Uniprot Name
TX2_HETMC
Alphafold ID
P60993
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P60993
Sequence
ECRYFWGECNDEMVCCEHLVCKEKWPITYKICVWDRTF
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Sequence Length
38
Mass (Da)
4765
Sequence Removed Signal Peptide
ECRYFWGECNDEMVCCEHLVCKEKWPITYKICVWDRTF
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Disulfide Bond
2-16;9-21;15-32
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Heteroscodra
Species: Heteroscodra maculata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.2 Inhibition rate .
300 nM
Modifier
 [1]
 Target Info    Kv4.1 Inhibition rate .
100 nM
Modifier
 [1]
 Target Info    Kv4.3 Inhibition rate .
100 nM
Modifier
 [1]
 Target Info    Kv4.2 Inhibition rate .
100 nM
Modifier
 [1]
 Target Info    Kv1.5 Inhibition rate
1 %
300 nM
Modifier
 [1]
 Target Info    Kv1.2 Inhibition rate
1 %
300 nM
Modifier
 [1]
 Target Info    Kv3.4 Inhibition rate
2 %
300 nM
Modifier
 [1]
 Target Info    Kv7.1 Inhibition rate
4 %
300 nM
Modifier
 [1]
 Target Info    Kv1.3 Inhibition rate
6 %
300 nM
Modifier
 [1]
 Target Info    Kv1.4 Inhibition rate
6 %
300 nM
Modifier
 [1]
 Target Info    Kv1.1 Inhibition rate
10 %
300 nM
Modifier
 [1]
 Target Info    Kv1.6 Inhibition rate
13 %
300 nM
Modifier
 [1]
 Target Info    Kv2.1 Inhibition rate
18 %
300 nM
Modifier
 [1]
 Target Info    Kv2.1 Inhibition rate
18 %
300 nM
Modifier
 [1]
References
Ref 1 Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol. 2002 Jul;62(1):48-57. doi: 10.1124/mol.62.1.48.
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