Peptide Information

General Information of This Peptide
Peptide ID
BTDP008652
Peptide Name
Delta/kappa-theraphotoxin-Pm1a
Species
Pelinobius muticus (King baboon spider) (Citharischius crawshayi)
Uniprot Name
TX1A_PELMU
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MKTFVFIVLVALAFVLTAAKEERANPSELVSALAELVMLDAERGVDKPGCRYLFGGCKSD
DDCCPRLGCKGKGHDYCAWDGTFSD
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Sequence Length
85
Mass (Da)
9224
Sequence Removed Signal Peptide
GVDKPGCRYLFGGCKSDDDCCPRLGCKGKGHDYCAWDGTFSD
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Disulfide Bond
50-64;57-69;63-77
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Pelinobius
Species: Pelinobius muticus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Effective concentration 50
1.1 μM
 .
Blocker
 [1]
 Target Info    Kv2.1 IC50
430 nM
 .
Blocker
 [1]
 Target Info    Kv2.1 IC50
0.43 μM
 .
Blocker
 [1]
References
Ref 1 Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2110932119. doi: 10.1073/pnas.2110932119.
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