Peptide Information

General Information of This Peptide
Peptide ID
BTDP008685
Peptide Name
Beta/kappa-theraphotoxin-Cg1a
Symonym
Jingzhaotoxin-3; Jingzhaotoxin-III; Peptide F5-20.38
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZTX3_CHIGU
Alphafold ID
P62520
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2I1T
Sequence
MKNTSILFILGLALLLVLAFEAQVGESDGECGGFWWKCGRGKPPCCKGYACSKTWGWCAV
EAP
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Sequence Length
63
Mass (Da)
6799
Signal Sequence
MKNTSILFILGLALLLVLA
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Sequence Removed Signal Peptide
FEAQVGESDGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP
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Disulfide Bond
31-46;38-51;45-58
PDB ID
2I1T
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
430 nM
 .
Modifier
 [1- 5]
 Target Info    Kv1.1 Inhibition rate .
1 μM
Modifier
 [1- 5]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Modifier
 [1- 5]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Modifier
 [1- 5]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Modifier
 [1- 5]
 Target Info    Kv3.1 Inhibition rate .
100 μM
Modifier
 [1- 5]
 Target Info    Kv4.1 Inhibition rate .
5 μM
Modifier
 [1- 5]
 Target Info    Kv4.2 Inhibition rate .
5 μM
Modifier
 [1- 5]
 Target Info    Kv4.3 Inhibition rate .
100 μM
Modifier
 [1- 5]
 Target Info    Kv11 Inhibition rate
11 %
100 μM
Modifier
 [1- 5]
 Target Info    Kv2.1 Inhibition rate
95 %
5 μM
Modifier
 [1- 5]
 Target Info    Kv2.1 IC50
710 nM
 .
Modifier
 [1- 5]
References
Ref 1 Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem. 2004 Jun 18;279(25):26220-6. doi: 10.1074/jbc.M401387200. Epub 2004 Apr 14.
Ref 2 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 3 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 4 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
Ref 5 Solution structure of Jingzhaotoxin-III, a peptide toxin inhibiting both Nav1.5 and Kv2.1 channels. Toxicon. 2007 Jul;50(1):135-43. doi: 10.1016/j.toxicon.2007.03.006. Epub 2007 Mar 16.
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