Peptide Information

General Information of This Peptide

Peptide ID	BTDP008536
Peptide Name	Potassium channel toxin gamma-KTx 2.1
Symonym	Neurotoxin BeKm-1
Species	Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Uniprot Name	KGX21_MESEU
Alphafold ID	Q9BKB7
3D Structure	Download 2D Sequence Download FASTA 3D Structure Download PDB Source RSCB PDB: 1J5J
Sequence	MKISFVLLLTLFICSIGWSEARPTDIKCSESYQCFPVCKSRFGKTNGRCVNGFCDCF Click to Show/Hide
Sequence Length	57
Mass (Da)	6452
Signal Sequence	MKISFVLLLTLFICSIGWSEA Click to Show/Hide
Sequence Removed Signal Peptide	RPTDIKCSESYQCFPVCKSRFGKTNGRCVNGFCDCF Click to Show/Hide
Disulfide Bond	28-49;34-54;38-56
PDB ID	1J5J , 1LGL
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Arthropoda Class: Arachnida Order: Scorpiones Family: Buthidae Genus: Mesobuthus Species: Mesobuthus eupeus

Full List of Activity Data of This Peptide Toxin

Target Name	Activity Data Type	Activity Data	Concentration	Note	Reference
Target Info Kv11.2	Dissociation constant	4.2 nM	.	Irreversible	[1- 10]
Target Info Kv11.2	Dissociation constant	4.2 nM	.	Blocker	[1- 10]
Target Info Kv11	Dissociation constant	7.7 nM	.	Blocker	[6]
Target Info Kv11/ERG	Dissociation constant	7.7 nM	.	Reversible	[1- 10]
Target Info Kv11.3	Dissociation constant	11.5 nM	.	Reversible	[1- 10]
Target Info Kv11.3	Dissociation constant	11.5 nM	.	Blocker	[6]
Target Info Kv11.1	Dissociation constant	19 nM	.	Reversible	[1- 10]
Target Info Kv11.1	Dissociation constant	19 nM	.	Blocker	[1- 10]
Target Info ERG2	Dissociation constant	77 nM	.	Reversible	[1- 10]
Target Info Kv11.2	Dissociation constant	77 nM	.	Blocker	[6]
Target Info Kv11.3	Dissociation constant	747 nM	.	Reversible	[1- 10]
Target Info Kv11.3	Dissociation constant	747 nM	.	Blocker	[1- 10]
Target Info Kir1.1	Inhibition rate	.	50 nM	Block macroscopic current	[1- 10]
Target Info KCa3.1	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info Kir1.1	Inhibition rate	.	100 nM	Blocker	[1- 10]
Target Info Kv1.2	Inhibition rate	.	50 nM	Block macroscopic current	[1- 10]
Target Info KCa3.1	Inhibition rate	.	100 nM	Blocker	[1]
Target Info Kv7.2	Inhibition rate	.	100 nM	Blocker	[1]
Target Info EAG1	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info Kv1.2	Inhibition rate	.	50 nM	Blocker	[1- 10]
Target Info Kv7.1	Inhibition rate	.	100 nM	Blocker	[1]
Target Info Kv7.4	Inhibition rate	.	100 nM	Blocker	[1]
Target Info Kv1.4	Inhibition rate	.	50 nM	Block macroscopic current	[1- 10]
Target Info Kv1.4	Inhibition rate	.	50 nM	Blocker	[1- 10]
Target Info KCa2	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info KCa2	Inhibition rate	.	100 nM	Blocker	[1]
Target Info Kv10	Inhibition rate	.	100 nM	Blocker	[1]
Target Info Kv2.1	Inhibition rate	.	50 nM	Block macroscopic current	[1- 10]
Target Info Kv2.1	Inhibition rate	.	50 nM	Blocker	[1- 10]
Target Info Kv4.3	Inhibition rate	.	50 nM	Block macroscopic current	[1- 10]
Target Info Kv4.3	Inhibition rate	.	50 nM	Blocker	[1- 10]
Target Info KCa1.1	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info KCa2.1	Inhibition rate	.	100 nM	Blocker	[1]
Target Info KCNQ1 and KCNE1	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info Kv7.2/7.3	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info Kv7.4	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info KCa2.1	Inhibition rate	.	100 nM	Block macroscopic current	[1- 10]
Target Info KCa1.1	Inhibition rate	.	100 nM	Blocker	[1]
Target Info Kv2.3	Inhibition rate	.	100 nM	Blocker	[1]
Target Info ELK1	Inhibition rate	9 %	100 nM	Block macroscopic current	[1- 10]
Target Info Kv12.1	Inhibition rate	10 %	100 nM	Blocker	[1]
Target Info ERG1	Inhibition rate	88 %	.	Block macroscopic current	[1- 10]
Target Info Kv11/ERG	IC50	3.3 nM	.	Reversible	[1- 10]
Target Info ERG1	IC50	7.6 nM	.	At room temperature	[1- 10]
Target Info Kv11	IC50	7.7 nM	.	Blocker	[1]
Target Info Kv11/ERG	IC50	11.9 nM	.	Reversible	[1- 10]
Target Info ERG1	IC50	15.3 nM	.	At 37°C	[1- 10]

References

Ref 1	An ERG channel inhibitor from the scorpion Buthus eupeus. J Biol Chem. 2001 Mar 30;276(13):9868-76. doi: 10.1074/jbc.M005973200. Epub 2001 Jan 2.
Ref 2	M-type K+ current inhibition by a toxin fron the scorpion Buthus eupeus. FEBS Lett. 1996 Apr 22;384(3):277-80. doi: 10.1016/0014-5793(96)00333-x.
Ref 3	BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1. Biophys J. 2003 May;84(5):3022-36. doi: 10.1016/S0006-3495(03)70028-9.
Ref 4	Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Lett. 2003 Jul 17;547(1-3):20-6. doi: 10.1016/s0014-5793(03)00662-8.
Ref 5	Unique interaction of scorpion toxins with the hERG channel. J Mol Recognit. 2004 May-Jun;17(3):209-17. doi: 10.1002/jmr.667.
Ref 6	Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol. 2006 May;69(5):1673-83. doi: 10.1124/mol.105.019729. Epub 2006 Feb 23.
Ref 7	BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. doi: 10.1124/jpet.110.176883. Epub 2010 Dec 23.
Ref 8	A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides. FEBS Lett. 2002 Dec 4;532(1-2):121-6. doi: 10.1016/s0014-5793(02)03652-9.
Ref 9	Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res. 2007 Feb;6(2):611-20. doi: 10.1021/pr060368g.
Ref 10	New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1. J Biol Chem. 2002 Nov 8;277(45):43104-9. doi: 10.1074/jbc.M204083200. Epub 2002 Jul 31.

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Peptide Information

Citation & Updates

Correspondence

DB Version: 2026-04

Update Cycle: 3-4 months

Data License: CC BY 4.0

Prof. Tingjun HOU ([tingjunhou@zju.edu.cn](mailto:tingjunhou@zju.edu.cn))

Prof. Zhonghua LIU ([liuzh@hunnu.edu.cn](mailto:liuzh@hunnu.edu.cn))

Prof. Xi ZHOU ([xizh@hunnu.edu.cn](mailto:xizh@hunnu.edu.cn))