Peptide Information

General Information of This Peptide
Peptide ID
BTDP008690
Peptide Name
Potassium channel toxin kappa-KTx 1.2
Symonym
Kappa-hefutoxin 2
Species
Chersonesometrus fulvipes (Indian black scorpion) (Heterometrus fulvipes)
Uniprot Name
KKX11_CHEFU
Alphafold ID
P82851
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1HP9
Sequence
GHACYRNCWREGNDEETCKERCG
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Sequence Length
23
Mass (Da)
2717
Sequence Removed Signal Peptide
GHACYRNCWREGNDEETCKERCG
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Disulfide Bond
4-22;8-18
PDB ID
1HP9 , 6ATS
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Chersonesometrus
Species: Chersonesometrus fulvipes
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . .
Blocker
 [1- 5]
 Target Info    Kv1.1 Dissociation constant
>150 μM
 .
Blocker
 [1- 5]
 Target Info    Kv1.3 Dissociation constant
40 μM
 .
Blocker
 [1- 5]
 Target Info    Kv1.3 Dissociation constant
40 μM
 .
Blocker
 [1- 5]
 Target Info    Kv1.2 Dissociation constant
150 μM
 .
Blocker
 [1- 5]
 Target Info    Kv1.2 Dissociation constant
150 μM
 .
Blocker
 [1- 5]
 Target Info    Kv1.4 Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Kv1.5 Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Kv2.1 Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Kv3.1 Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Kv4.2 Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Kv11.1 Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Shaker-IR Inhibition rate . .
Blocker
 [1- 5]
 Target Info    Kv1 Inhibition rate .
40 μM
Blocker
 [1- 5]
 Target Info    Kv1.6 Inhibition rate
16.6 %
40 μM
Blocker
 [1- 5]
 Target Info    Kv10 IC50
26 μM
 .
Blocker
 [1- 5]
 Target Info    Kv11.1 IC50
26 μM
 .
Blocker
 [1- 5]
References
Ref 1 kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity. J Biol Chem. 2002 Aug 16;277(33):30040-7. doi: 10.1074/jbc.M111258200. Epub 2002 May 28.
Ref 2 Synthesis and characterization of amino acid deletion analogs of -hefutoxin 1, a scorpion toxin on potassium channels. Toxicon. 2013 Sep;71:25-30. doi: 10.1016/j.toxicon.2013.05.010. Epub 2013 May 29.
Ref 3 Expanding the pharmacological profile of -hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1. Peptides. 2017 Dec;98:43-50. doi: 10.1016/j.peptides.2016.08.008. Epub 2016 Aug 28.
Ref 4 Assignment of voltage-gated potassium channel blocking activity to kappa-KTx1.3, a non-toxic homologue of kappa-hefutoxin-1, from Heterometrus spinifer venom. Biochem Pharmacol. 2005 Feb 15;69(4):669-78. doi: 10.1016/j.bcp.2004.10.018. Epub 2004 Dec 29.
Ref 5 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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