Peptide Information

General Information of This Peptide
Peptide ID
BTDP008399
Peptide Name
Kappa-theraphotoxin-Scg1a
Symonym
SGTx1; SgTx-I
Species
Stromatopelma calceatum griseipes (Feather leg baboon tarantula) (Scodra griseipes)
Uniprot Name
TX1_STRGF
Alphafold ID
P56855
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1LA4
Sequence
TCRYLFGGCKTTADCCKHLACRSDGKYCAWDGTF
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Sequence Length
34
Mass (Da)
3782
Sequence Removed Signal Peptide
TCRYLFGGCKTTADCCKHLACRSDGKYCAWDGTF
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Disulfide Bond
2-16;9-21;15-28
PDB ID
1LA4
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Stromatopelma
Species: Stromatopelma calceatum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
2.7 μM
 .
Modifier
 [1- 7]
 Target Info    Kv2.1 Dissociation constant
2.7 μM
 .
Modifier
 [1- 7]
References
Ref 1 Isolation, amino acid sequence and functional assays of SGTx1. The first toxin purified from the venom of the spider scodra griseipes. Eur J Biochem. 1999 Oct;265(2):572-9. doi: 10.1046/j.1432-1327.1999.00726.x.
Ref 2 Conformational study of a new SGTx1 neurotoxin from the spider Scodra griseipes using mass spectrometry. Rapid Commun Mass Spectrom. 2001;15(8):579-85. doi: 10.1002/rcm.261.
Ref 3 Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J Gen Physiol. 2004 Apr;123(4):455-67. doi: 10.1085/jgp.200309005.
Ref 4 SGTx1, a Kv channel gating-modifier toxin, binds to the interfacial region of lipid bilayers. Biophys J. 2007 Jan 1;92(1):L07-9. doi: 10.1529/biophysj.106.098681. Epub 2006 Oct 27.
Ref 5 Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophys J. 2010 Jul 21;99(2):638-46. doi: 10.1016/j.bpj.2010.04.061.
Ref 6 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 7 Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating. Biochemistry. 2004 Feb 3;43(4):890-7. doi: 10.1021/bi0353373.
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