General Information of This Target
Target ID
BTDT10189
Target Name
Potassium voltage-gated channel subfamily A member 4
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    HgTX1 (A19Y,Y37F) . . [1]
 Toxin Info    Venom peptide Sh41 Effect . [2]
 Toxin Info    Venom peptide Sh42 Effect . [2]
 Toxin Info    U-scoloptoxin(15)-Sm2a Effect . [3], [4]
 Toxin Info    Neurotoxic enhancer CSTX-13 Inhibition rate . [5], [6], [7], [8]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a Inhibition rate . [9- 15]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a Inhibition rate . [9- 15]
 Toxin Info    Conopeptide Y-Pl1 Inhibition rate . [16]
 Toxin Info    Kappa-theraphotoxin-Ps1a Inhibition rate . [17], [18], [19]
 Toxin Info    Kappa-theraphotoxin-Ps1b Inhibition rate . [17]
 Toxin Info    Delta/kappa-actitoxin-Avd4a Inhibition rate . [20- 25]
 Toxin Info    Kappa-theraphotoxin-Cg2a Inhibition rate . [10- 26]
 Toxin Info    Mambaquaretin-1 Inhibition rate . [27], [28], [29]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [30], [31]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [30], [31]
 Toxin Info    Potassium channel toxin gamma-KTx 2.1 Inhibition rate . [32- 41]
 Toxin Info    Toxin PhcrTx2 Inhibition rate . [42]
 Toxin Info    Conopeptide Y-Fe1 Inhibition rate . [16]
 Toxin Info    Alpha/kappa-conotoxin pl14a Inhibition rate . [43]
 Toxin Info    Potassium channel toxin gamma-KTx 2.1 Inhibition rate . [32- 41]
 Toxin Info    U21-theraphotoxin-Cg1b Inhibition rate . [13], [10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Inhibition rate . [10- 45]
 Toxin Info    Beta/kappa-theraphotoxin-Cg1a Inhibition rate . [10- 47]
 Toxin Info    Potassium channel toxin kappa-KTx 1.2 Inhibition rate . [48- 52]
 Toxin Info    Potassium channel toxin kappa-KTx 5.1 Inhibition rate
13 %
[53], [54], [55], [56]
 Toxin Info    Kappa-actitoxin-Ael2a Inhibition rate
35 %
[23- 61]
 Toxin Info    Kappa-stichotoxin-She3a IC50
0.31 nM
[23- 75]
 Toxin Info    Beta-theraphotoxin-Gr1a IC50
>200 μM
[76], [77], [78], [79]
 Toxin Info    Beta-theraphotoxin-Gr1b IC50
>200 μM
[77], [78], [79]
 Toxin Info    Kappa-theraphotoxin-Gr2c IC50
>200 μM
[80], [77], [78], [79]
 Toxin Info    Kappa-theraphotoxin-Gr3a IC50
>200 μM
[77- 85]
 Toxin Info    Conopeptide Y-Pl1 IC50
>50 μM
[16]
 Toxin Info    Conopeptide Y-Fe1 IC50
>50 μM
[16]
 Toxin Info    M-theraphotoxin-Gr1a IC50
53 - 85 μM
[77- 96]
References
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Ref 65 Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30;274(31):21885-92. doi: 10.1074/jbc.274.31.21885.
Ref 66 Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr;67(4):1369-81. doi: 10.1124/mol.104.008193. Epub 2005 Jan 21.
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Ref 86 cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon. 2003 Sep;42(3):263-74. doi: 10.1016/s0041-0101(03)00141-7.
Ref 87 Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583-98. doi: 10.1085/jgp.115.5.583.
Ref 88 Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem. 2002 Sep 13;277(37):34443-50. doi: 10.1074/jbc.M202715200. Epub 2002 Jun 24.
Ref 89 Tarantula peptide inhibits atrial fibrillation. Nature. 2001 Jan 4;409(6816):35-6. doi: 10.1038/35051165.
Ref 90 Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004 Jul 8;430(6996):235-40. doi: 10.1038/nature02743.
Ref 91 Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-8. doi: 10.1016/j.bbrc.2005.12.046. Epub 2005 Dec 19.
Ref 92 Effects of tarantula toxin GsMTx4 on the membrane motor of outer hair cells. Neurosci Lett. 2006 Aug 14;404(1-2):213-6. doi: 10.1016/j.neulet.2006.05.059. Epub 2006 Jun 22.
Ref 93 Molecular dynamics simulations of a stretch-activated channel inhibitor GsMTx4 with lipid membranes: two binding modes and effects of lipid structure. Biophys J. 2007 Jun 15;92(12):4233-43. doi: 10.1529/biophysj.106.101071. Epub 2007 Mar 23.
Ref 94 Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers?. Biophys J. 2007 Aug 15;93(4):L20-2. doi: 10.1529/biophysj.107.112375. Epub 2007 Jun 15.
Ref 95 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 96 Fast desensitization of acetylcholine receptors induced by a spider toxin. Channels (Austin). 2021 Dec;15(1):507-515. doi: 10.1080/19336950.2021.1961459.
Ref 97 Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA(2)-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom. Toxins (Basel). 2019 Jun 12;11(6):335. doi: 10.3390/toxins11060335.
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