Peptide Information

General Information of This Peptide
Peptide ID
BTDP008542
Peptide Name
Potassium channel toxin kappa-KTx 5.1
Symonym
HelaTx1
Species
Heterometrus laoticus (Thai giant scorpion)
Uniprot Name
KKX51_HETLA
Alphafold ID
P0DJ41
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2NDD
Sequence
MKLLPLLFVILIVCAILPDEASCDQSELERKEENFKDESREIVKRSCKKECSGSRRTKKC
MQKCNREHGHGR
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Sequence Length
72
Mass (Da)
8380
Signal Sequence
MKLLPLLFVILIVCAILPDEASC
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Sequence Removed Signal Peptide
DQSELERKEENFKDESREIVKRSCKKECSGSRRTKKCMQKCNREHGHGR
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Disulfide Bond
47-64;51-60
PDB ID
2NDD
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus laoticus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate
13 %
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 Inhibition rate
20 %
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.6 Inhibition rate
59.8 %
30 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate
60 %
30 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1 Effective concentration 50
9.9 μM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
578.5 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1 IC50
0.5785 - 9.9 μM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new -KTX subfamily. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.
Ref 2 Effects of deletion and insertion of amino acids on the activity of HelaTx1, a scorpion toxin on potassium channels. Toxicon. 2016 Mar 1;111:1-5. doi: 10.1016/j.toxicon.2015.12.014. Epub 2015 Dec 24.
Ref 3 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 4 Solution structure and functional analysis of HelaTx1: the first toxin member of the -KTx5 subfamily. BMB Rep. 2020 May;53(5):260-265. doi: 10.5483/BMBRep.2020.53.5.256.
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