Peptide Information

General Information of This Peptide
Peptide ID
BTDP008745
Peptide Name
HgTX1 (A19Y,Y37F)
Symonym
HgTX1 (A19Y,Y37F)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
TVIDVKCTSPKQCLPPCKAQFGIRAGAKCMNGKCKCYPH
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Mutant Sequence
TVIDVKCTSPKQCLPPCKYQFGIRAGAKCMNGKCKCFPH
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Sequence Length
39
Mass(Da)
4296
Sequence Removed Signal Peptide
TVIDVKCTSPKQCLPPCKYQFGIRAGAKCMNGKCKCFPH
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 . . .
Blocker
 [1]
 Target Info    Kv1.5 . . .
Blocker
 [1]
 Target Info    Kv1.1 Dissociation constant
0.12 pM
 .
Blocker
 [1]
 Target Info    Kv Dissociation constant
0.15 pM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
0.17 pM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
0.21 pM
 .
Blocker
 [1]
 Target Info    Kv1.6 Dissociation constant
1 pM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
0.067 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.153 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
0.29 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
10 nM
 .
Blocker
 [1]
References
Ref 1 Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem. 1998 Jan 30;273(5):2639-44. doi: 10.1074/jbc.273.5.2639.
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