Peptide Information

General Information of This Peptide
Peptide ID
BTDP008425
Peptide Name
Mambaquaretin-1
Symonym
Upsilon-Da2a
Species
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Uniprot Name
MAMB1_DENAN
Alphafold ID
A0A1Z0YU59
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5M4V
Sequence
RPSFCNLPVKPGPCNGFFSAFYYSQKTNKCHSFTYGGCKGNANRFSTIEKCRRTCVG
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Sequence Length
57
Mass (Da)
6377
Sequence Removed Signal Peptide
RPSFCNLPVKPGPCNGFFSAFYYSQKTNKCHSFTYGGCKGNANRFSTIEKCRRTCVG
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Disulfide Bond
5-55;14-38;30-51
PDB ID
5M4V
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis angusticeps
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    V2R Inhibition constant
5.02 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv11 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv1.5 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv1.6 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv3.1 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv11.1 Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Shaker-IR Inhibition rate .
100 μM
Blocker
 [1], [2], [3]
 Target Info    Kv1.1 IC50
8.2 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.1 IC50
8.2 μM
 .
Blocker
 [1], [2], [3]
 Target Info    trypsin IC50
14.8 μM
 .
Blocker
 [1], [2], [3]
References
Ref 1 Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19.
Ref 2 A snake toxin as a theranostic agent for the type 2 vasopressin receptor. Theranostics. 2020 Sep 18;10(25):11580-11594. doi: 10.7150/thno.47485. eCollection 2020.
Ref 3 A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28.
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