Peptide Information

General Information of This Peptide
Peptide ID
BTDP008355
Peptide Name
Conopeptide Y-Pl1
Symonym
CPY-Pl1
Species
Conus planorbis (Planorbis cone)
Uniprot Name
CPY1_CONPO
Alphafold ID
B3SVF0
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B3SVF0
Sequence
MSKLGVVLFVFLLLLPLAAPQPVGDQPADQPADRNAEARARFLHPFQYYTLYRYLTRFLH
RYPIYYIRY
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Sequence Length
69
Mass (Da)
8236
Signal Sequence
MSKLGVVLFVFLLLLPLAAP
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Sequence Removed Signal Peptide
QPVGDQPADQPADRNAEARARFLHPFQYYTLYRYLTRFLHRYPIYYIRY
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus planorbis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate .
50 μM
 . [1]
 Target Info    Kv1.4 Inhibition rate .
50 μM
 . [1]
 Target Info    Kv1.5 Inhibition rate .
5 μM
 . [1]
 Target Info    Kv1.6 IC50
170 nM
 . . [1]
 Target Info    Kv1.6 IC50
170 nM
 . . [1]
 Target Info    Kv1.5 IC50
>5 μM
 . . [1]
 Target Info    Kv1.3 IC50
>50 μM
 . . [1]
 Target Info    Kv1.4 IC50
>50 μM
 . . [1]
 Target Info    Kv1.2 IC50
2 μM
 . . [1]
 Target Info    Kv1.2 IC50
2 μM
 . . [1]
References
Ref 1 Tyrosine-rich conopeptides affect voltage-gated K+ channels. J Biol Chem. 2008 Aug 22;283(34):23026-32. doi: 10.1074/jbc.M800084200. Epub 2008 May 27.
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