Peptide Information

General Information of This Peptide
Peptide ID
BTDP008679
Peptide Name
Kappa-theraphotoxin-Gr3a
Symonym
Voltage sensor toxin 1
Species
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Uniprot Name
VSTX1_GRARO
Alphafold ID
P60980
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1S6X
Sequence
MKTSVFVLVLGLVLLFAVSFATEMEESARECGKFMWKCKNSNDCCKDLVCSSRWKWCVLA
SPF
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Sequence Length
63
Mass (Da)
7175
Sequence Removed Signal Peptide
ECGKFMWKCKNSNDCCKDLVCSSRWKWCVLASPF
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Disulfide Bond
31-45;38-50;44-57
PDB ID
1S6X , 2N1N
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola rosea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
2 mM
Modifier
 [1- 6]
 Target Info    Kv1.4 Inhibition rate .
2 mM
Modifier
 [1- 6]
 Target Info    KvAP IC50
25 nM
 .
Modifier
 [1- 6]
 Target Info    Kv1.1 IC50
>200 μM
 .
Modifier
 [1- 6]
 Target Info    Kv1.4 IC50
>200 μM
 .
Modifier
 [1- 6]
 Target Info    Kv11 IC50
7.4 μM
 .
Modifier
 [1- 6]
 Target Info    Kv11.2 IC50
45 μM
 .
Modifier
 [1- 6]
 Target Info    Kv11.2 IC50
45 μM
 .
Modifier
 [1- 6]
 Target Info    Kv11.3 IC50
55 μM
 .
Modifier
 [1- 6]
 Target Info    Kv11.3 IC50
55 μM
 .
Modifier
 [1- 6]
References
Ref 1 Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature. 2003 Mar 13;422(6928):180-5. doi: 10.1038/nature01473. Epub 2003 Mar 2.
Ref 2 Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. doi: 10.1074/jbc.M109.054718. Epub 2009 Dec 2.
Ref 3 A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature. 2004 Jul 8;430(6996):232-5. doi: 10.1038/nature02632.
Ref 4 Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry. 2004 Aug 10;43(31):10071-9. doi: 10.1021/bi049463y.
Ref 5 Vstx1, a modifier of Kv channel gating, localizes to the interfacial region of lipid bilayers. Biochemistry. 2006 Oct 3;45(39):11844-55. doi: 10.1021/bi061111z.
Ref 6 Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel. Biochemistry. 2005 Apr 26;44(16):6015-23. doi: 10.1021/bi0477034.
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