General Information of This Target
Target ID
BTDT10201
Target Name
Potassium voltage-gated channel subfamily C member 1
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Potassium channel toxin alpha-KTx 1.1 Dissociation constant
>1 μM
[1- 21]
 Toxin Info    U-scoloptoxin(15)-Sm2a Effect . [22], [23]
 Toxin Info    Venom peptide Sh41 Effect . [24]
 Toxin Info    Venom peptide Sh42 Effect . [24]
 Toxin Info    Neurotoxic enhancer CSTX-13 Inhibition rate . [25], [26], [27], [28]
 Toxin Info    Kappa-actitoxin-Bgr1a Inhibition rate . [29- 36]
 Toxin Info    Kappa-theraphotoxin-Cg2a Inhibition rate . [37], [38], [39]
 Toxin Info    Kappa-theraphotoxin-Ps1a Inhibition rate . [40], [41], [42]
 Toxin Info    Kappa-theraphotoxin-Ps1b Inhibition rate . [40]
 Toxin Info    Toxin PhcrTx2 Inhibition rate . [43]
 Toxin Info    Mambaquaretin-1 Inhibition rate . [44], [45], [46]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [47], [48]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [47], [48]
 Toxin Info    U21-theraphotoxin-Cg1b Inhibition rate . [37], [38]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Inhibition rate . [38- 50]
 Toxin Info    Beta/kappa-theraphotoxin-Cg1a Inhibition rate . [37- 53]
 Toxin Info    Potassium channel toxin kappa-KTx 1.2 Inhibition rate . [54- 58]
 Toxin Info    Delta/kappa-actitoxin-Avd4a Inhibition rate
22 %
[35- 63]
 Toxin Info    Delta/kappa-actitoxin-Avd4a Inhibition rate
45 %
[35- 63]
 Toxin Info    DeltaKappa-actitoxin-Avd4b Inhibition rate
50 %
[35- 60]
 Toxin Info    DeltaKappa-actitoxin-Avd4b Inhibition rate
52 %
[35- 60]
References
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Ref 33 Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain. J Biol Chem. 2002 Feb 8;277(6):3886-93. doi: 10.1074/jbc.M109886200. Epub 2001 Nov 13.
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Ref 39 Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007 Oct;50(5):646-52. doi: 10.1016/j.toxicon.2007.05.009. Epub 2007 Jun 3.
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Ref 41 Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. J Med Chem. 2014 Aug 14;57(15):6623-31. doi: 10.1021/jm500687u. Epub 2014 Jul 24.
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Ref 44 Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19.
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Ref 52 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
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