Target Information

General Information of This Target
Target ID
BTDT00181
Target Name
Sodium channel protein
Target Bioclass
Transporter and channel
Uniprot ID
Q9BMQ4
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MATPASSNPGPSSTMPTAQKPAPGKAQVKPFTKESLERMENKTVQLVKEYGFQPRRKLSV
EDGSVLPGKFEPFPSRLYGRPLEEIDNFIYDETFCVVSKRFRKNYIHRFTATNSFFIFSP
WNAIRRTCIFLSTNQYFDYVVMITILLNCVFLAMTDTVEEAEYIFLAIYTAEMIIKSIAK
GFILNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTI
INALLHSFKQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRKIDSSNASDIEWTEWVN
DEENWLFTEEDEPVICGNVTGARHCPFGYFCLQVGENPNHGYTSFDNFLWSMLTTFQLIT
LDYWENVYNMVLPSCGPISVVFFTVVVFFGSFYLINLMLAVVALSYEEEAEITQEERRKD
LTDHRDDSTFSFDPSKINVKQLDKKNRRRVDSRKGVLLASYTRSRKKTRRRKRPRAGGSG
SGGENNNNNNNGQSEHGGSRSATPSPRHSGSGPCPPSAPSPESRPHSLTLSPPSVVKGLS
NPEQEEEEEQQQEPLQQEEQPPQQPPQLQRFLQPPIAAPAPAEHASDTLHPVNTLGKLGP
PHRGQLLASRHPSSNNSDSNNRESSLDDSGVVDDHEEGDVTSEDVAQIPNVVQRVEPVTV
ALSSKEIRVIKCNGVSPGHGTQKHLYTLPSDYLSHIVVLNDLPDRNCDKCTQCCVDYDGW
LRFQSGLYKVVRDPLFDLLITLCIILNTMFLAMEHHGMSESVRQALDIGNKVFTSIFTLE
CFLKILALSKEYFACGWNIFDLIIVSASLLDLSFELMDSLVVLRCLRLLRVLKLARSWTT
MKVLLSIIISTIGALGNLTFVLVIVIYIFAVIGMQLFSKDYTADKFYPDPIPRWNFNDFF
HSFMMVFRILCGEWTEPLWDCMRAEKLTGAETCFAIFLPALVMGNFMVLDLFLALLLNSF
NSEELKSKKEEVGEESKLARSFERLRSIVRKKRHAKEKTENEQNMRLEEMVHEVMSRHAA
EKCYTASGVHETVIGRTIDHKRHAALVQETMSLQRAQRQQQEQQNDGSRYNPDAENNEDE
DRNGQHSPTFPRVVNSIVTGELEDRKYSVSCHENLNKHMEDKRYSLVLPKSAQSALHDED
NKQSEDSVLHPLVDKRTSLTTQQTESKDESNPEESIELEVLDKAPGETETMLPPAETPKK
TRSITKKPWNALAPYVDELTVGGRRDSQGHYVDGMGSFPGFARNKTVKVPQDCFPQHCYQ
RCLCCDKYLETPCGQRWTHIRTQVLSVVDTPVFEWFILVLIFASSITLCFEDIYLDQNLV
LKNVLYWTNLGFCALFSIEMMLKWLALGFWRYFTSFWTILDFIIVFVSIFSLLMEENENL
KVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFF
GGKFFKCVDDEGNLLPISVVDGMLECEDKNYSWVNSKITFDNVGNAYLALFQVATFEGWM
EVMADAVDERGVNMQPQREANLYAYLYFVVFIVCGSFFTLNLFIGVIIDNFNMLKKKYEG
GVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPMNQVLATFYDLSNSRRFEIAIFVLIFL
NMLTMGIEHYQQPHAVFFILEVSNAFFTTVFGLEAIVKIIGLRYHYFTVPWNLFDFLLVV
ASILGILMEDIMIDFPVSPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI
GALLALITFIYAIIGMSVFGHVKQQGALDDMVNFETFGRSMQLLFRLMTSAGWNDVVGSL
MIQPPNCNPTYNNQPNGDCGSPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEE
IGIVEDDLEMFYIRWSKYDPHATQFIRFSQLSDFIASLDPPLGIPKPNTVALVSFNLPIA
RGNKIHCLDILHSLVKYVLGHVEETDDFKKLQDQMDIKFKKQFPTRKELEIVSSTRIWKR
QDKAARTIQGAFREYIRLKREREREPLDLEDEMTQTSSPGGGWQSRLSAFLHVHRGSRAS
SRKSSRASDASELSELGGAWLNLPLLFLSGAHQGQTEDLLDPGHGSNGNSNVCITVSEPS
PDTGPPLNEETKPSTSMVLPVSVKDELREPLTVGDVSILVTQPSPEGAGVPVDRGTEDRR
PSNSSGESFHQIDSSESRTMPGVETTLSSSGTTTAALDRHPLGLLRPVGTVLSLFPMQLG
NGGDLGSTPRKPASEAVTGPVDMHPLRVRPGTAFSLPPSEIVKPLAKSSPERRRARSRRR
PSDGTLVRVLVHRESEESNDDKGS

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Family
the sodium channel (TC 1.A.1.10) family
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

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Taxonomy ID
6973
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Blattodea
Family: Blattellidae
Genus: Blattella
Species: Blattella germanica
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    N.vectensis toxin 4 Effect . [1]
 Toxin Info    N.vectensis toxin 5 Effect . [1]
 Toxin Info    Beta-toxin Tf1a Inhibition rate . [2]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [3], [4]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [3], [4]
 Toxin Info    Potassium channel toxin AbeTx1 Inhibition rate . [5]
 Toxin Info    Nemertide alpha-6 Effective concentration 50
2.6 nM
 [6], [7]
 Toxin Info    Nemertide alpha-5 Effective concentration 50
7.8 nM
 [6], [7]
 Toxin Info    Nemertide alpha-1 Effective concentration 50
8.6 nM
 [6], [7], [8]
 Toxin Info    Nemertide alpha-1 Effective concentration 50
8.6 nM
 [6], [7], [8]
 Toxin Info    Nemertide alpha-7 Effective concentration 50
9.5 nM
 [6], [7]
 Toxin Info    Nemertide alpha-4 Effective concentration 50
11.1 nM
 [6], [7]
 Toxin Info    Nemertide alpha-2 Effective concentration 50
87.2 nM
 [6], [7]
 Toxin Info    Nemertide alpha-3 Effective concentration 50
102.2 nM
 [6], [7]
 Toxin Info    Nemertide alpha-3 Effective concentration 50
102.2 nM
 [6], [7]
 Toxin Info    Nemertide alpha-2 Effective concentration 50
1.2967 μM
 [6], [7]
References
Ref 1 The Birth and Death of Toxins with Distinct Functions: A Case Study in the Sea Anemone Nematostella. Mol Biol Evol. 2019 Sep 1;36(9):2001-2012. doi: 10.1093/molbev/msz132.
Ref 2 Subtype Specificity of -Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels. Toxins (Basel). 2018 Aug 22;10(9):339. doi: 10.3390/toxins10090339.
Ref 3 Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY. J Biol Chem. 2015 May 8;290(19):12195-209. doi: 10.1074/jbc.M115.637611. Epub 2015 Mar 19.
Ref 4 K(V)1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity. Neuropharmacology. 2018 Dec;143:228-238. doi: 10.1016/j.neuropharm.2018.09.030. Epub 2018 Sep 22.
Ref 5 AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K? Channels Activation. Mar Drugs. 2018 Oct 1;16(10):360. doi: 10.3390/md16100360.
Ref 6 Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Sci Rep. 2018 Mar 22;8(1):4596. doi: 10.1038/s41598-018-22305-w.
Ref 7 Functional Characterization of the Nemertide Family of Peptide Toxins. J Nat Prod. 2021 Aug 27;84(8):2121-2128. doi: 10.1021/acs.jnatprod.1c00104. Epub 2021 Aug 16.
Ref 8 Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report. Front Cardiovasc Med. 2020 Jul 24;7:117. doi: 10.3389/fcvm.2020.00117. eCollection 2020.
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