Peptide Information

General Information of This Peptide
Peptide ID
BTDP008370
Peptide Name
DeltaKappa-actitoxin-Avd4b
Symonym
Antihypertensive protein BDS-2; Blood depressing substance II
Species
Anemonia sulcata (Mediterranean snakelocks sea anemone)
Uniprot Name
BDS2_ANESU
Alphafold ID
P59084
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P59084
Sequence
AAPCFCPGKPDRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
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Sequence Length
43
Mass (Da)
4782
Sequence Removed Signal Peptide
AAPCFCPGKPDRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
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Disulfide Bond
4-39;6-32;22-40
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anemonia
Species: Anemonia sulcata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv Dissociation constant
19 nM
 .
Modifier
 [1], [2], [3]
 Target Info    Kv3.1 Inhibition rate
50 %
 .
At a voltage of +40 mV
 [1], [2], [3]
 Target Info    Kv3.2 Inhibition rate
50 %
 .
At a voltage of +40 mV
 [1], [2], [3]
 Target Info    Kv3.4 Inhibition rate
50 %
 .
At a voltage of +40 mV
 [1], [2], [3]
 Target Info    Kv3.1 Inhibition rate
52 %
500 nM
Modifier
 [1], [2], [3]
 Target Info    Nav1.7 Effective concentration 50
300 nM
 .
At a voltage of +40 mV
 [1], [2], [3]
 Target Info    Kv3.4 IC50
56 nM
 .
Modifier
 [1], [2], [3]
 Target Info    Kv3.4 IC50
750 nM
 .
Modifier
 [1], [2], [3]
References
Ref 1 Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J Biol Chem. 1998 Mar 20;273(12):6744-9. doi: 10.1074/jbc.273.12.6744.
Ref 2 Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci. 2005 Sep 21;25(38):8735-45. doi: 10.1523/JNEUROSCI.2119-05.2005.
Ref 3 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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