Peptide Information

General Information of This Peptide
Peptide ID
BTDP008377
Peptide Name
Kappa-actitoxin-Bgr1a
Symonym
Potassium channel toxin Bgk
Species
Bunodosoma granuliferum (Red warty sea anemone)
Uniprot Name
K1B_BUNGR
Alphafold ID
P29186
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1BGK
Sequence
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKTCELC
   Click to Show/Hide
Sequence Length
37
Mass (Da)
4282
Sequence Removed Signal Peptide
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKTCELC
   Click to Show/Hide
Disulfide Bond
2-37;11-30;20-34
PDB ID
1BGK
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Bunodosoma
Species: Bunodosoma granuliferum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Dissociation constant
6 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.1 Dissociation constant
6 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 Dissociation constant
10 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 Dissociation constant
10 - 39 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 Dissociation constant
15 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.2 Dissociation constant
15 nM
 .
Blocker
 [2]
 Target Info    Kv1.1 Dissociation constant
17 nM
 .
Blocker
 [9]
 Target Info    KCa3.1 Dissociation constant
172 nM
 .
Blocker
 [3]
 Target Info    KCa3.1 Dissociation constant
172 nM
 .
Blocker
 [1- 8]
 Target Info    Kv1.6 Inhibition constant
0.013 nM
 .
Blocker
 [5]
 Target Info    Kv1.1 Inhibition constant
0.034 nM
 .
Blocker
 [5]
 Target Info    Kv1.2 Inhibition constant
0.066 nM
 .
Blocker
 [5]
 Target Info    Kv1.3 Inhibition constant
0.777 nM
 .
Blocker
 [5]
 Target Info    Kv1.2-1.1 Inhibition constant
8 nM
 .
Blocker
 [5]
 Target Info    Kv3.1 Inhibition rate .
125 nM
Blocker
 [2]
 Target Info    Kv3.1 Inhibition rate .
125 nM
Blocker
 [1- 8]
 Target Info    Kv1 IC50
3.6 nM
 .
Blocker
 [1- 8]
References
Ref 1 A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity. Biochim Biophys Acta. 1993 May 7;1157(1):86-92. doi: 10.1016/0304-4165(93)90082-j.
Ref 2 A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity. Eur J Biochem. 1997 Feb 15;244(1):192-202. doi: 10.1111/j.1432-1033.1997.00192.x.
Ref 3 Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30;274(31):21885-92. doi: 10.1074/jbc.274.31.21885.
Ref 4 Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity. J Biol Chem. 1999 Dec 10;274(50):35653-61. doi: 10.1074/jbc.274.50.35653.
Ref 5 Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain. J Biol Chem. 2002 Feb 8;277(6):3886-93. doi: 10.1074/jbc.M109886200. Epub 2001 Nov 13.
Ref 6 Peptide fingerprinting of the neurotoxic fractions isolated from the secretions of sea anemones Stichodactyla helianthus and Bunodosoma granulifera. New members of the APETx-like family identified by a 454 pyrosequencing approach. Peptides. 2012 Mar;34(1):26-38. doi: 10.1016/j.peptides.2011.10.011. Epub 2011 Oct 12.
Ref 7 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 8 On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem. 1997 Feb 14;272(7):4302-9. doi: 10.1074/jbc.272.7.4302.
Ref 9 Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers. J Biol Chem. 2002 Oct 4;277(40):37406-13. doi: 10.1074/jbc.M206205200. Epub 2002 Jul 19.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.