Target Information

General Information of This Target
Target ID
BTDT10205
Target Name
Potassium voltage-gated channel subfamily D member 1
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Potassium channel toxin alpha-KTx 6 hetlaxin Inhibition rate . [1]
 Toxin Info    Mu-scoloptoxin(15)-Ssm1a Inhibition rate . [2]
 Toxin Info    Beta/kappa-theraphotoxin-Cg1a Inhibition rate . [3- 7]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a Inhibition rate
25 %
 [4- 10]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Inhibition rate
35 %
 [5- 12]
 Toxin Info    U21-theraphotoxin-Cg1b Inhibition rate
62 %
 [4], [5]
 Toxin Info    Kappa-theraphotoxin-Cg1a 4 Inhibition rate
Moderate .
 [4- 12]
 Toxin Info    Kappa-theraphotoxin-Cg1a 6 Inhibition rate
Moderate .
 [4- 12]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Inhibition rate
Moderate .
 [5- 12]
 Toxin Info    Kappa-theraphotoxin-Cg1a 3 Inhibition rate
Moderate .
 [4- 12]
 Toxin Info    Kappa-theraphotoxin-Cg1a 5 Inhibition rate
Moderate .
 [4- 12]
 Toxin Info    Kappa-theraphotoxin-Cg1a 2 Inhibition rate
Moderate .
 [4- 12]
 Toxin Info    Delta-theraphotoxin-Hm1a IC50
280 nM
 [13], [14], [15], [16]
 Toxin Info    Kappa-theraphotoxin-Cg2a IC50
363 nM
 [4- 17]
 Toxin Info    U21-theraphotoxin-Cg1b IC50
1.17 μM
 [4], [5]
References
Ref 1 Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis. J Biol Chem. 2021 Jan-Jun;296:100670. doi: 10.1016/j.jbc.2021.100670. Epub 2021 Apr 15.
Ref 2 Centipedes subdue giant prey by blocking KCNQ channels. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1646-1651. doi: 10.1073/pnas.1714760115. Epub 2018 Jan 22.
Ref 3 Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem. 2004 Jun 18;279(25):26220-6. doi: 10.1074/jbc.M401387200. Epub 2004 Apr 14.
Ref 4 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 5 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 6 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
Ref 7 Solution structure of Jingzhaotoxin-III, a peptide toxin inhibiting both Nav1.5 and Kv2.1 channels. Toxicon. 2007 Jul;50(1):135-43. doi: 10.1016/j.toxicon.2007.03.006. Epub 2007 Mar 16.
Ref 8 Isolation and characterization of Jingzhaotoxin-V, a novel neurotoxin from the venom of the spider Chilobrachys jingzhao. Toxicon. 2007 Mar 1;49(3):388-99. doi: 10.1016/j.toxicon.2006.10.012. Epub 2006 Nov 6.
Ref 9 Molecular surface of JZTX-V (-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel). 2014 Jul 23;6(7):2177-93. doi: 10.3390/toxins6072177.
Ref 10 Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V. PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018.
Ref 11 Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels. Biochemistry. 2006 Dec 26;45(51):15591-600. doi: 10.1021/bi061457+.
Ref 12 The tarantula toxin jingzhaotoxin-XI (-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5. Toxicon. 2014 Dec 15;92:6-13. doi: 10.1016/j.toxicon.2014.09.002. Epub 2014 Sep 18.
Ref 13 Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol. 2002 Jul;62(1):48-57. doi: 10.1124/mol.62.1.48.
Ref 14 Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.
Ref 15 A selective Na(V)1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol. 2020 Nov;181:113991. doi: 10.1016/j.bcp.2020.113991. Epub 2020 Apr 23.
Ref 16 Selective Na(V)1.1 activation rescues Dravet syndrome mice from seizures and premature death. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.
Ref 17 Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007 Oct;50(5):646-52. doi: 10.1016/j.toxicon.2007.05.009. Epub 2007 Jun 3.
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