| Ref 1 |
Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function. Cell Mol Life Sci. 2010 Aug;67(16):2799-813. doi: 10.1007/s00018-010-0359-x. Epub 2010 Apr 6.
|
| Ref 2 |
Isolation, synthesis and characterization of -TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19.
|
| Ref 3 |
Precursor structure of omega-conotoxin GVIA determined from a cDNA clone. Toxicon. 1992 Sep;30(9):1111-6. doi: 10.1016/0041-0101(92)90056-b.
|
| Ref 4 |
Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry. 1984 Oct 23;23(22):5087-90. doi: 10.1021/bi00317a001.
|
| Ref 5 |
Peptide neurotoxins from fish-hunting cone snails. Science. 1985 Dec 20;230(4732):1338-43. doi: 10.1126/science.4071055.
|
| Ref 6 |
Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds. Biopolymers. 1986;25 Suppl:S61-8.
|
| Ref 7 |
Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem Biophys Res Commun. 1993 Aug 16;194(3):1292-6. doi: 10.1006/bbrc.1993.1964.
|
| Ref 8 |
Hydroxyl group of Tyr13 is essential for the activity of omega-conotoxin GVIA, a peptide toxin for N-type calcium channel. J Biol Chem. 1994 Sep 30;269(39):23876-8.
|
| Ref 9 |
Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues. J Biol Chem. 1997 May 2;272(18):12014-23. doi: 10.1074/jbc.272.18.12014.
|
| Ref 10 |
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem. 2000 Nov 10;275(45):35335-44. doi: 10.1074/jbc.M002252200.
|
| Ref 11 |
A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity. Biochemistry. 2001 Dec 4;40(48):14567-75. doi: 10.1021/bi002871r.
|
| Ref 12 |
Three-dimensional structure of omega-conotoxin GVIA determined by 1H NMR. Biochem Biophys Res Commun. 1993 May 14;192(3):1238-44. doi: 10.1006/bbrc.1993.1549.
|
| Ref 13 |
Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis. Biochemistry. 1993 Jul 27;32(29):7396-405. doi: 10.1021/bi00080a009.
|
| Ref 14 |
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin. J Mol Biol. 1993 Nov 20;234(2):405-20. doi: 10.1006/jmbi.1993.1595.
|
| Ref 15 |
Solution structure of the calcium channel antagonist omega-conotoxin GVIA. Protein Sci. 1993 Oct;2(10):1591-603. doi: 10.1002/pro.5560021005.
|
| Ref 16 |
Refined solution structure of omega-conotoxin GVIA: implications for calcium channel binding. J Pept Res. 1999 Mar;53(3):343-51. doi: 10.1034/j.1399-3011.1999.00040.x.
|
| Ref 17 |
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels. J Mol Recognit. 2000 Mar-Apr;13(2):55-70. doi: 10.1002/(SICI)1099-1352(200003/04)13:2<55::AID-JMR488>3.0.CO;2-O.
|
| Ref 18 |
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol Pharmacol. 2010 Feb;77(2):139-48. doi: 10.1124/mol.109.058834. Epub 2009 Nov 5.
|
| Ref 19 |
Effects of arginine 10 to lysine substitution on -conotoxin CVIE and CVIF block of Cav2.2 channels. Br J Pharmacol. 2014 Jul;171(13):3313-27. doi: 10.1111/bph.12686.
|
| Ref 20 |
Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc Biol Sci. 2004 Jun 7;271(1544):1165-74. doi: 10.1098/rspb.2004.2708.
|
| Ref 21 |
Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol Phylogenet Evol. 2010 Jul;56(1):1-12. doi: 10.1016/j.ympev.2010.03.029. Epub 2010 Apr 2.
|
| Ref 22 |
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom. Biochemistry. 1987 Apr 21;26(8):2086-90. doi: 10.1021/bi00382a004.
|
| Ref 23 |
Determination of disulfide bridge pattern in omega-conopeptides. Int J Pept Protein Res. 1995 Sep-Oct;46(3-4):320-5. doi: 10.1111/j.1399-3011.1995.tb00604.x.
|
| Ref 24 |
Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers. Biochem Biophys Res Commun. 1995 Jan 17;206(2):449-54. doi: 10.1006/bbrc.1995.1063.
|
| Ref 25 |
Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Curr Med Chem. 2004 Dec;11(23):3029-40. doi: 10.2174/0929867043363884.
|
| Ref 26 |
Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA. Neuropharmacology. 2016 Feb;101:137-45. doi: 10.1016/j.neuropharm.2015.08.047. Epub 2015 Sep 4.
|
| Ref 27 |
Pre-clinical evaluation of voltage-gated calcium channel blockers derived from the spider P.?nigriventer in glioma progression. Toxicon. 2017 Apr;129:58-67. doi: 10.1016/j.toxicon.2017.02.001. Epub 2017 Feb 13.
|
| Ref 28 |
Novel analgesic -conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.
|
| Ref 29 |
A novel -conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. Acta Pharm Sin B. 2021 Sep;11(9):2685-2693. doi: 10.1016/j.apsb.2021.03.001. Epub 2021 Mar 18.
|
| Ref 30 |
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA. Biochemistry. 1995 Aug 15;34(32):10256-65. doi: 10.1021/bi00032a020.
|
| Ref 31 |
Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy. FEBS Lett. 1995 Aug 21;370(3):163-9. doi: 10.1016/0014-5793(95)00819-u.
|
| Ref 32 |
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202. J Mol Biol. 1996 Oct 25;263(2):297-310. doi: 10.1006/jmbi.1996.0576.
|
| Ref 33 |
Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. J Mol Biol. 1999 Jun 25;289(5):1405-21. doi: 10.1006/jmbi.1999.2817.
|
| Ref 34 |
Structural and dynamic characterization of omega-conotoxin MVIIA: the binding loop exhibits slow conformational exchange. Biochemistry. 2000 Apr 11;39(14):3908-19. doi: 10.1021/bi992651h.
|
| Ref 35 |
Solution structure and backbone dynamics of an omega-conotoxin precursor. Protein Sci. 2001 Mar;10(3):538-50. doi: 10.1110/ps.30701.
|
| Ref 36 |
Structure of human Ca(v)2.2 channel blocked by the painkiller ziconotide. Nature. 2021 Aug;596(7870):143-147. doi: 10.1038/s41586-021-03699-6. Epub 2021 Jul 7.
|
| Ref 37 |
Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3. Mol Pharmacol. 1998 Aug;54(2):407-18. doi: 10.1124/mol.54.2.407.
|
| Ref 38 |
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron. 1992 Jul;9(1):69-77. doi: 10.1016/0896-6273(92)90221-x.
|
| Ref 39 |
Tyr13 is essential for the binding of omega-conotoxin MVIIC to the P/Q-type calcium channel. Biochem Biophys Res Commun. 1995 Sep 14;214(2):305-9. doi: 10.1006/bbrc.1995.2288.
|
| Ref 40 |
Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins. Biochemistry. 2008 Feb 12;47(6):1741-51. doi: 10.1021/bi701934m. Epub 2008 Jan 12.
|
| Ref 41 |
An improved diagnostic assay for Lambert-Eaton myasthenic syndrome. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):85-7. doi: 10.1136/jnnp.58.1.85.
|
| Ref 42 |
Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis. J Mol Biol. 1995 Apr 21;248(1):106-24. doi: 10.1006/jmbi.1995.0205.
|
| Ref 43 |
Analgesic effect of highly reversible -conotoxin FVIA on N type Ca2+ channels. Mol Pain. 2010 Dec 21;6:97. doi: 10.1186/1744-8069-6-97.
|
| Ref 44 |
cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena. Toxicon. 2003 Dec;42(7):715-23. doi: 10.1016/j.toxicon.2003.08.007.
|
| Ref 45 |
Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena. Toxicon. 1993 Aug;31(8):969-78. doi: 10.1016/0041-0101(93)90256-i.
|
| Ref 46 |
Assignment of the three disulfide bridges of huwentoxin-I, a neurotoxin from the spider selenocosmia huwena. J Protein Chem. 1993 Dec;12(6):735-40. doi: 10.1007/BF01024931.
|
| Ref 47 |
Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena. Toxicon. 1997 Jan;35(1):39-45. doi: 10.1016/s0041-0101(96)00072-4.
|
| Ref 48 |
[Chemical synthesis and characterization of R20A-HWTX-I, a mutant of huwentoxin-I with single residue replacement]. Sheng Wu Gong Cheng Xue Bao. 2000 Jul;16(4):490-4.
|
| Ref 49 |
The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena. Toxicon. 2000 Sep;38(9):1237-46. doi: 10.1016/s0041-0101(99)00224-x.
|
| Ref 50 |
The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study. Toxicon. 2001 Apr;39(4):491-8. doi: 10.1016/s0041-0101(00)00150-1.
|
| Ref 51 |
Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats. Toxicon. 2005 Jan;45(1):15-20. doi: 10.1016/j.toxicon.2004.08.018.
|
| Ref 52 |
The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun. 2007 Jun 8;357(3):579-83. doi: 10.1016/j.bbrc.2007.02.168. Epub 2007 Apr 9.
|
| Ref 53 |
Functional expression of spider neurotoxic peptide huwentoxin-I in E. coli. PLoS One. 2011;6(6):e21608. doi: 10.1371/journal.pone.0021608. Epub 2011 Jun 23.
|
| Ref 54 |
Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
|
| Ref 55 |
Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution. J Protein Chem. 1997 Aug;16(6):565-74. doi: 10.1023/a:1026314722607.
|
| Ref 56 |
Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides. 1999;20(10):1139-44. doi: 10.1016/s0196-9781(99)00116-3.
|
| Ref 57 |
The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus. J Nat Prod. 2003 Sep;66(9):1276-9. doi: 10.1021/np030099y.
|
| Ref 58 |
SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. Br J Pharmacol. 2005 Jul;145(6):728-39. doi: 10.1038/sj.bjp.0706223.
|
| Ref 59 |
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29. doi: 10.1124/mol.105.015941. Epub 2005 Nov 2.
|
| Ref 60 |
Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J Biol Chem. 2016 Jul 1;291(27):13974-13986. doi: 10.1074/jbc.M116.725978. Epub 2016 Apr 22.
|
| Ref 61 |
Discovery and mode of action of a novel analgesic -toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.
|
| Ref 62 |
Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
|
