Peptide Information

General Information of This Peptide
Peptide ID
BTDP008175
Peptide Name
Omega-conotoxin SO-3
Symonym
SO3
Species
Conus striatus (Striated cone)
Uniprot Name
O16O3_CONST
Alphafold ID
Q9XZK2
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1FYG
Sequence
MKLTCMVIVAVLLLTACQLITADDSRGTQKHRTLRSKTKLSMSTRCKAAGKPCSRIAYNC
CTGSCRSGKCG
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Sequence Length
71
Mass (Da)
7628
Signal Sequence
MKLTCMVIVAVLLLTACQLITA
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Sequence Removed Signal Peptide
DDSRGTQKHRTLRSKTKLSMSTRCKAAGKPCSRIAYNCCTGSCRSGKCG
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Disulfide Bond
46-61;53-65;60-70
PDB ID
1FYG
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.2 IC50
160 nM
 . . [1], [2], [3], [4]
References
Ref 1 Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides. 1999;20(10):1139-44. doi: 10.1016/s0196-9781(99)00116-3.
Ref 2 The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus. J Nat Prod. 2003 Sep;66(9):1276-9. doi: 10.1021/np030099y.
Ref 3 SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. Br J Pharmacol. 2005 Jul;145(6):728-39. doi: 10.1038/sj.bjp.0706223.
Ref 4 Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA. Neuropharmacology. 2016 Feb;101:137-45. doi: 10.1016/j.neuropharm.2015.08.047. Epub 2015 Sep 4.
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