Peptide Information

General Information of This Peptide
Peptide ID
BTDP008014
Peptide Name
Omega conotoxin-CVIE
Symonym
Omega conotoxin-CVIE-2
Species
Conus catus (Cat cone)
Uniprot Name
O16E_CONCT
Alphafold ID
Q9N633
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q9N633
Sequence
VVIVAVLLLTACQLITANDSRGTQKHRALRSDTKLSMSTRCKGKGASCRRTSYDCCTGSC
RSGRCG
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Sequence Length
66
Mass (Da)
7053
Sequence Removed Signal Peptide
VVIVAVLLLTACQLITANDSRGTQKHRALRSDTKLSMSTRCKGKGASCRRTSYDCCTGSC
RSGRCG
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Disulfide Bond
41-56;48-60;55-65
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus catus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.2 IC50
0.12 nM
 .
When Cav2.2/CACNA1B is only expressed with the ancillary subunit CACNB3
 [1], [2], [3]
 Target Info    Cav2.2 IC50
2.6 nM
 .
Cav2.2/CACNA1B expressed with the ancillary subunits CACNA2D1 and CACNB3
 [1], [2], [3]
References
Ref 1 Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc Biol Sci. 2004 Jun 7;271(1544):1165-74. doi: 10.1098/rspb.2004.2708.
Ref 2 Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol Pharmacol. 2010 Feb;77(2):139-48. doi: 10.1124/mol.109.058834. Epub 2009 Nov 5.
Ref 3 Effects of arginine 10 to lysine substitution on -conotoxin CVIE and CVIF block of Cav2.2 channels. Br J Pharmacol. 2014 Jul;171(13):3313-27. doi: 10.1111/bph.12686.
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