Peptide Information

General Information of This Peptide
Peptide ID
BTDP005976
Peptide Name
MVIIC
Symonym
SNX-230;Omega-conotoxin MVIIC
Species
Conus magus (Magical cone)
Uniprot Name
O17C_CONMA
Alphafold ID
P37300
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1CNN
Sequence
TRCKGKGAPCRKTMYDCCSGSCGRRGKCG
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Sequence Length
29
Mass (Da)
3071
Sequence Removed Signal Peptide
TRCKGKGAPCRKTMYDCCSGSCGRRGKCG
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Disulfide Bond
3-18;10-22;17-28
PDB ID
1CNN , 1OMN , 1V4Q
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus magus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.1 IC50
0.6 nM
 . . [1- 7]
 Target Info    Cav2.2 IC50
7 nM
 . . [1- 7]
References
Ref 1 A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron. 1992 Jul;9(1):69-77. doi: 10.1016/0896-6273(92)90221-x.
Ref 2 Tyr13 is essential for the binding of omega-conotoxin MVIIC to the P/Q-type calcium channel. Biochem Biophys Res Commun. 1995 Sep 14;214(2):305-9. doi: 10.1006/bbrc.1995.2288.
Ref 3 Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem. 2000 Nov 10;275(45):35335-44. doi: 10.1074/jbc.M002252200.
Ref 4 Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins. Biochemistry. 2008 Feb 12;47(6):1741-51. doi: 10.1021/bi701934m. Epub 2008 Jan 12.
Ref 5 An improved diagnostic assay for Lambert-Eaton myasthenic syndrome. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):85-7. doi: 10.1136/jnnp.58.1.85.
Ref 6 Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis. J Mol Biol. 1995 Apr 21;248(1):106-24. doi: 10.1006/jmbi.1995.0205.
Ref 7 Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. J Mol Biol. 1999 Jun 25;289(5):1405-21. doi: 10.1006/jmbi.1999.2817.
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