Peptide Information

General Information of This Peptide
Peptide ID
BTDP005311
Peptide Name
Omega conotoxin-CVIF
Species
Conus catus (Cat cone)
Uniprot Name
O16F_CONCT
Alphafold ID
P0DQD4
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQD4
Sequence
CKGKGASCRRTSYDCCTGSCRLGRC
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Sequence Length
25
Mass (Da)
2672
Sequence Removed Signal Peptide
CKGKGASCRRTSYDCCTGSCRLGRC
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Disulfide Bond
1-16;8-20;15-25
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus catus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.2 IC50
0.1 nM
 .
When Cav2.2/CACNA1B is only expressed with the ancillary subunit CACNB3
 [1], [2]
 Target Info    Cav2.2 IC50
19.9 nM
 .
Cav2.2/CACNA1B expressed with the ancillary subunits CACNA2D1 and CACNB3
 [1], [2]
References
Ref 1 Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol Pharmacol. 2010 Feb;77(2):139-48. doi: 10.1124/mol.109.058834. Epub 2009 Nov 5.
Ref 2 Effects of arginine 10 to lysine substitution on -conotoxin CVIE and CVIF block of Cav2.2 channels. Br J Pharmacol. 2014 Jul;171(13):3313-27. doi: 10.1111/bph.12686.
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