Peptide Information

General Information of This Peptide
Peptide ID
BTDP008401
Peptide Name
Kunitz-type conkunitzin-S1
Symonym
Conk-S1
Species
Conus striatus (Striated cone)
Uniprot Name
VKTS1_CONST
Alphafold ID
P0C1X2
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1Y62
Sequence
MEGRRFAAVLILTICMLAPGTGTLLPKDRPSLCDLPADSGSGTKAEKRIYYNSARKQCLR
FDYTGQGGNENNFRRTYDCQRTCLYT
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Sequence Length
86
Mass (Da)
9661
Signal Sequence
MEGRRFAAVLILPICMLAPGAVA
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Sequence Removed Signal Peptide
LLPKDRPSLCDLPADSGSGTKAEKRIYYNSARKQCLRFDYTGQGGNENNFRRTYDCQRTC
LYT
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Disulfide Bond
33-83;58-79
PDB ID
1Y62 , 2CA7 , 6Q61 , 6Q6C , 6YHY
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
20 μM
 . [1], [2], [3]
 Target Info    Kv1.6 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv2.1 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv1.5 Inhibition rate .
50 μM
 . [1], [2], [3]
 Target Info    Kv3.2 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv4.1 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    KCa1.1 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv10.1 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    KCa1.1 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv3.4 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv2.3 Inhibition rate .
100 μM
 . [1], [2], [3]
 Target Info    Kv10.2 Inhibition rate .
30 μM
 . [1], [2], [3]
 Target Info    Kv4.2 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate
15 %
5 μM
 . [1], [2], [3]
 Target Info    Kv1 Inhibition rate
20 %
5 μM
 . [1], [2], [3]
 Target Info    Kv1.7 Inhibition rate
65 %
1 μM
 . [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate
70 %
5 μM
 . [1], [2], [3]
 Target Info    ShakerKD Effective concentration 50
0.95 nM
 . . [1], [2], [3]
 Target Info    Shaker-IR IC50
0.95 nM
 . . [1], [2], [3]
 Target Info    Shaker-IR IC50
1.33 nM
 . . [1], [2], [3]
 Target Info    Kv1.7-1.2 IC50
180 nM
 . . [1], [2], [3]
 Target Info    Kv1.7-1.2 IC50
390 nM
 . . [1], [2], [3]
 Target Info    Kv1.7 IC50
439 nM
 . . [1], [2], [3]
 Target Info    Shaker IC50
502 nM
 . . [1], [2], [3]
 Target Info    Kv1.2 IC50
3.4 μM
 . . [1], [2], [3]
 Target Info    Kv1.2 IC50
4.18 μM
 . . [1], [2], [3]
References
Ref 1 Production of recombinant Conkunitzin-S1 in Escherichia coli. Protein Expr Purif. 2006 Jun;47(2):640-4. doi: 10.1016/j.pep.2006.01.019. Epub 2006 Feb 20.
Ref 2 Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J Biol Chem. 2005 Jun 24;280(25):23766-70. doi: 10.1074/jbc.C500064200. Epub 2005 Apr 15.
Ref 3 Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):980-90. doi: 10.1107/S0907444906021123. Epub 2006 Aug 19.
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